Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 6/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.37 |
| ▸ | HTR1A | P08908 | 4/20 | 0.36 |
| ▸ | PGR | P06401 | 1/20 | 0.35 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | KLK7 | P49862 | 1/20 | 0.35 |
| ▸ | RORC | P51449 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4674205 | 0.87 | HTR6 (0.51) | HTR6SLC6A4HTR1APGR | |
| SCHEMBL4670792 | 0.84 | HTR1A (0.37) | HTR6SLC6A4HTR1AIRAK4RORC | |
| SCHEMBL4671138 | 0.75 | RORC (0.39) | HTR6RORC | |
| SCHEMBL4671137 | 0.75 | RORC (0.39) | HTR6RORC | |
| SCHEMBL4671109 | 0.74 | SMN1; SMN2 (0.44) | HTR6 | |
| SCHEMBL4670879 | 0.73 | HTR6 (0.45) | HTR6SLC6A4HTR1ACNR1CNR2 | |
| SCHEMBL4673194 | 0.73 | MMP2 (0.42) | RORC | |
| SCHEMBL1366189 | 0.69 | CYP11B2 (0.48) | HTR6SLC6A4 | |
| SCHEMBL6636075 | 0.68 | SLC6A4 (0.53) | SLC6A4HTR1ACNR1CNR2RORC | |
| Ethylene SCHEMBL7478496 | 0.67 | SLC6A4 (0.51) | SLC6A4HTR1ACNR1CNR2RORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0958287-B2 | SULFAMIDE-METALLOPROTEASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2008-04-09 | — | — | EP | disclosed |
| EP-0958287-B1 | SULFAMIDE-METALLOPROTEASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2002-09-11 | — | — | EP | disclosed |