Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.38 |
| ▸ | THRB | P10828 | 2/20 | 0.38 |
| ▸ | BLM | P54132 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | APEX1 | P27695 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | F2 | P00734 | 1/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | WRN | Q14191 | 1/20 | 0.38 |
| ▸ | PTPN11 | Q06124 | 5/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL828238 | 0.83 | HDAC6 (0.59) | HDAC6ENPP2L3MBTL1TDP1THRB | |
| SCHEMBL6027004 | 0.80 | ALDH1A1 (0.46) | HDAC6ENPP2L3MBTL1TDP1THRB | |
| SCHEMBL1160168 | 0.80 | HDAC6 (0.46) | HDAC6ENPP2L3MBTL1TDP1THRB | |
| SCHEMBL4318643 | 0.80 | HDAC6 (0.46) | HDAC6ENPP2L3MBTL1TDP1THRB | |
| SCHEMBL12754678 | 0.80 | HDAC6 (0.46) | HDAC6ENPP2L3MBTL1TDP1THRB | |
| SCHEMBL2817420 | 0.79 | HDAC6 (0.44) | HDAC6ENPP2L3MBTL1TDP1THRB | |
| SCHEMBL10770660 | 0.79 | LMNA (0.45) | HDAC6ENPP2L3MBTL1APEX1KMT2A | |
| SCHEMBL318730 | 0.79 | HDAC6 (0.67) | HDAC6ENPP2 | |
| Water SCHEMBL28362650 | 0.79 | HDAC6 (0.44) | HDAC6ENPP2L3MBTL1TDP1THRB | |
| Water SCHEMBL28362573 | 0.78 | HDAC6 (0.43) | HDAC6ENPP2L3MBTL1TDP1THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1392639-B1 | PYRUVATE DERIVATIVES | GALILEO LAB INC (US) | 2008-09-17 | — | — | EP | disclosed |
| EP-1392639-A4 | PYRUVATE DERIVATIVES | GALILEO LAB INC (US) | 2006-01-25 | — | — | EP | disclosed |
| US-6916850-B2 | Pyruvate derivatives | GALILEO PHARMACEUTICALS, INC. (US) | 2005-07-12 | — | — | US | disclosed |
| US-6900218-B2 | Pyruvate derivatives | GALILEO PHARMACEUTICALS, INC. (US) | 2005-05-31 | — | — | US | disclosed |
| EP-1392639-A1 | PYRUVATE DERIVATIVES | Galileo Laboratories, Inc. (US) | 2004-03-03 | — | — | EP | disclosed |
| US-20030013656-A1 | Pyruvate derivatives | ALLOY VENTURES, INC. | 2003-01-16 | — | — | US | disclosed |
| US-20030013846-A1 | Pyruvate derivatives | ALLOY VENTURES, INC. | 2003-01-16 | — | — | US | disclosed |
| US-20030013847-A1 | Cytoprotective agents | MONSANTO TECHNOLOGY LLC | 2003-01-16 | — | — | US | disclosed |
| US-20030013657-A1 | Pyruvate derivatives | MONSANTO TECHNOLOGY, LLC. | 2003-01-16 | — | — | US | disclosed |
| WO-2002090314-A1 | PYRUVATE DERIVATIVES | GALILEO LABORATORIES, INC. (US) | 2002-11-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030013847-A1 | Cytoprotective agents | PC, PDK1, PDK2 | HDAC6 694/4885ENPP2 2246/4885L3MBTL1 473/4885 |
| US-20030013657-A1 | Pyruvate derivatives | PC, PDK1, PDK4 | HDAC6 1208/4885ENPP2 2763/4885L3MBTL1 430/4885 |
| US-20030013846-A1 | Pyruvate derivatives | PC, PDK1, PDK4 | HDAC6 1208/4885ENPP2 2763/4885L3MBTL1 430/4885 |
| US-20030013656-A1 | Pyruvate derivatives | PC, PDK1, PDK4 | HDAC6 1208/4885ENPP2 2763/4885L3MBTL1 430/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.