SCHEMBL467533

SCHEMBL467533

[c]1ccc(-n2cnc3ccccc32)cc1

nearest known ligand 0.72

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
HTT P42858 3/20 0.72
FGFR1 P11362 6/20 0.64
POLB P06746 1/20 0.51
KDM4E B2RXH2 1/20 0.49
ALDH1A1 P00352 1/20 0.49
RAB9A P51151 1/20 0.49
SMN1; SMN2 Q16637 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3419279 0.86 HTT (0.88) HTTFGFR1POLBKDM4EALDH1A1
SCHEMBL30402227 0.86 HTT (0.88) HTTFGFR1POLBKDM4EALDH1A1
SCHEMBL157265 0.84 HTT (1.00) HTTFGFR1
Benzene SCHEMBL14876970 0.84 HTT (1.00) HTTFGFR1
Iodide SCHEMBL30645138 0.82 HTT (0.96) HTTFGFR1
SCHEMBL27724758 0.82 HTT (0.96) HTTFGFR1
SCHEMBL4891428 0.82 HTT (0.96) HTTFGFR1
SCHEMBL467858 0.82 HTT (0.96) HTTFGFR1
SCHEMBL2531256 0.81 HTT (0.78) HTTFGFR1POLBKDM4EALDH1A1
SCHEMBL16147268 0.81 HTT (0.66) HTTFGFR1POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 229 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230220161-A1 POLYIMIDE PRECURSOR PREPARED BY USING POLYCYCLIC MONOMER INCLUDING TRIFLUOROMETHYL GROUP AND FLEXIBLE POLYIMIDE OBTAINED BY USING THE SAME KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) 2023-07-13 US claimed
CN-115010701-A Preparation method of nitrogen-containing heterocyclic derivative 浙江百可半导体材料有限公司 2022-09-06 CN claimed
CN-114361341-A Laminated image pickup device and image pickup module 索尼公司 2022-04-15 CN claimed
CN-114316478-A Graphene semiconductive shielding material for cable and preparation method thereof 段恩成 2022-04-12 CN claimed
CN-107534050-B Image sensor, laminated image pickup device, and image pickup module 索尼公司 2021-12-14 CN claimed
US-20200274077-A1 PHOTOELECTRIC CONVERSION ELEMENT AND IMAGING APPARATUS SONY CORPORATION (JP) 2020-08-27 US claimed
CN-111316459-A Photoelectric conversion element and imaging device 索尼公司 2020-06-19 CN claimed
US-10566548-B2 Image sensor, stacked imaging device and imaging module SONY CORPORATION (JP) 2020-02-18 US claimed
EP-3300114-B1 IMAGING ELEMENT, MULTILAYER IMAGING ELEMENT AND IMAGING DEVICE SONY CORP (JP) 2020-01-08 EP claimed
US-10076517-B2 Methods and pharmaceutical compositions for the treatment of fibrosis INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE KA RECHERCHE MÉDICALE (FR) 2018-09-18 US claimed
WO-2012059442-A2 NEUROTRYPSIN INHIBITORS NEUROTUNE AG (CH) 2012-05-10 WO claimed
EP-2421825-A1 AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS Janssen Pharmaceutica N.V. (BE) 2012-02-29 EP claimed
EP-2421848-A1 AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS Janssen Pharmaceutica N.V. (BE) 2012-02-29 EP claimed
US-20100331300-A1 AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS JANSSEN PHARMACEUTICA NV (BE) 2010-12-30 US claimed
US-20100324014-A1 AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS JANSSEN PHARMACEUTICA NV (BE) 2010-12-23 US claimed
CN-101875637-A Organic material and application thereof in organic electroluminescence devices BEIJING VISIONOX TECHNOLOGY CO 2010-11-03 CN claimed
WO-2010124119-A1 AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS JANSSEN PHARMACEUTICA NV (BE) 2010-10-28 WO claimed
WO-2010124108-A1 AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS JANSSEN PHARMACEUTICA NV (BE) 2010-10-28 WO claimed
EP-1326864-A2 ARYL OR HETEROARYL FUSED IMIDAZOLE COMPOUNDS AS ANTI-INFLAMMATORY AND ANALGESIC AGENTS PFIZER PHARMACEUTICALS INC. (JP) 2003-07-16 EP claimed
WO-2002032900-A2 ARYL OR HETEROARYL FUSED IMIDAZOLE COMPOUNDS AS ANTI-INFLAMMATORY AND ANALGESIC AGENTS PFIZER PHARMACEUTICALS INC. (JP) 2002-04-25 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10076517-B2 Methods and pharmaceutical compositions for the treatment of fibrosis LIPA, MGLL, PNLIP HTT 4502/4885FGFR1 828/4885POLB 3008/4885
US-20100331300-A1 AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS PNLIP, LPL, LIPA HTT 2522/4885FGFR1 1817/4885POLB 3399/4885
US-20100324014-A1 AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS PNLIP, LPL, LIPA HTT 2522/4885FGFR1 1817/4885POLB 3399/4885
US-20200274077-A1 PHOTOELECTRIC CONVERSION ELEMENT AND IMAGING APPARATUS PPOX, JUP, L1CAM HTT 4831/4885FGFR1 4364/4885POLB 2158/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.