Known targets — ChEMBL curated mechanism
DHFRGARTPTGFRPTGIRPTGS1PTGS2TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8envmurAthyA
The experimentally established mechanism targets of Tromethamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | LCK | P06239 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.30 |
| ▸ | TSHR | P16473 | 3/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trolamine SCHEMBL10479188 | 0.80 | MEN1 (0.59) | MEN1LMNAKMT2AALDH1A1TSHR | |
| Trolamine SCHEMBL460514 | 0.80 | MEN1 (0.59) | MEN1LMNAKMT2AALDH1A1TSHR | |
| Tromethamine SCHEMBL2130065 | 0.79 | MEN1 (0.50) | MEN1LMNAKMT2A | |
| Tromethamine SCHEMBL3761763 | 0.78 | MEN1 (0.77) | MEN1LMNAKMT2AALDH1A1TSHR | |
| Trolamine SCHEMBL11046229 | 0.78 | MEN1 (0.56) | MEN1LMNAKMT2AALDH1A1TSHR | |
| Trolamine SCHEMBL5144735 | 0.76 | MEN1 (0.53) | MEN1LMNAKMT2A | |
| Tromethamine SCHEMBL4365613 | 0.76 | MEN1 (0.71) | MEN1LMNAKMT2AALDH1A1TSHR | |
| Monoethanolamine SCHEMBL21635468 | 0.76 | ALDH1A1 (0.57) | LCKALDH1A1TSHR | |
| Tromethamine SCHEMBL11438714 | 0.76 | MEN1 (0.71) | MEN1LMNAKMT2AALDH1A1TSHR | |
| Tromethamine SCHEMBL1792376 | 0.76 | MEN1 (0.71) | MEN1LMNAKMT2AALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 42 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2386394-B1 | DURABLE THERMOSET BINDER COMPOSITIONS FROM 5-CARBON REDUCING SUGARS AND USE AS WOOD BINDERS | ROHM & HAAS (US) | 2020-06-10 | — | — | EP | disclosed |
| US-20150071954-A1 | STABLE PEPTIDE MIMETICS OF THE HIV-1 GP41 PRE-HAIRPIN INTERMEDIATE | MERCK SHARP & DOHME CORP. | 2015-03-12 | — | — | US | disclosed |
| US-8883886-B2 | Durable thermoset binder compositions from 5-carbon reducing sugars and use as wood binders | ROHM AND HAAS COMPANY (US) | 2014-11-11 | — | — | US | disclosed |
| US-20130146439-A1 | PHOTO-INDUCED REDUCTION-OXIDATION CHEMISTRY OF CARBON NANOTUBES | ROSTOVTSEV VSEVOLOD (US) | 2013-06-13 | — | — | US | disclosed |
| EP-2386394-A1 | Durable thermoset binder compositions from 5-carbon reducing sugars and use as wood binders | Rohm and Haas Company (US) | 2011-11-16 | — | — | EP | disclosed |
| US-20110263757-A1 | DURABLE THERMOSET BINDER COMPOSITIONS FROM 5-CARBON REDUCING SUGARS AND USE AS WOOD BINDERS | ROHM AND HAAS COMPANY | 2011-10-27 | — | — | US | disclosed |
| US-20110252750-A1 | MEDICINE PACKING UNIT AND PACKING CONTROL METHOD THEREOF | YUYAMA MFG. CO., LTD. (JP) | 2011-10-20 | — | — | US | disclosed |
| US-8038853-B2 | Photo-induced reduction-oxidation chemistry of carbon nanotubes | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 2011-10-18 | — | — | US | disclosed |
| US-7947371-B2 | Single-walled carbon nanotube composites | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 2011-05-24 | — | — | US | disclosed |
| US-7927802-B2 | DNA-based functionalization of single walled carbon nanotubes for directed assembly | INTERNATIONAL BUSINESS MACHINES CORPORATION (US) | 2011-04-19 | — | — | US | disclosed |
| EP-1562692-A2 | SEPARATION OF CARBON NANOTUBES DISPERSED BY NUCLEIC ACIDS | E.I.Du pont de nemours and company (US) | 2005-08-17 | — | — | EP | disclosed |
| US-20050009039-A1 | Using electrophoresis to separate DNA conjugated nanostructures; semiconductors; biosensors | E.I. DU PONT DE NEMOURS AND COMPANY | 2005-01-13 | — | — | US | disclosed |
| WO-2004104004-A2 | TRIAZA-SPIRO COMPOUNDS AS NOCICEPTIN ANALOGUES AND USES THEREOF | ZEALAND PHARMA A/S (DK) | 2004-12-02 | — | — | WO | disclosed |
| US-20040132072-A1 | Dispersion of carbon nanotubles by nucleic acids | E.I. DU PONT DE NEMOURS AND COMPANY | 2004-07-08 | — | — | US | disclosed |
| WO-2004048256-A2 | SEPARATION OF CARBON NANOTUBES DISPERSED BY NUCLEIC ACIDS | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 2004-06-10 | — | — | WO | disclosed |
| WO-2004048255-A2 | DISPERSION OF CARBON NANOTUBES BY NUCLEIC ACIDS | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 2004-06-10 | — | — | WO | disclosed |
| US-6057493-A | PLASMID FOR PRODUCTION OF TRANSGENIC PLANTS WITH REDUCTION IN STARCH CONCENTRATION AND INCREASE IN SUCROSE CONCENTRATION; FOR THE EXTRACTION OF SUGAR | HOECHST SCHERING AGREVO GMBH (DE) | 2000-05-02 | — | — | US | disclosed |
| US-5917127-A | Plasmids useful for and methods of preparing transgenic plants with modifications of habit and yield | HOECHST SCHERING AGREVO GMBH (DE) | 1999-06-29 | — | — | US | disclosed |
| US-5492820-A | PLASMID INCLUDING DNA SEQUENCE CODING FOR ESCHERICHIA COLI INORGANIC PYROPHOSPHATASE; PRODUCES TRANSFORMED PLANT CELL EXPRESSING ADDITIONAL PYROPHOSPHATASE ACTIVITY, INCREASING CONCENTRATION OF SOLUBLE SUGARS | INSTITUT FUR GENBIOLOGISCHE FORSCHUNG BERLIN GMBH (DE) | 1996-02-20 | — | — | US | disclosed |
| US-5436394-A | Plasmid for the preparation of transgenic plants with a change in habit and yield | SCHERING AKTIENGESELLSCHAFT (DE) | 1995-07-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150071954-A1 | STABLE PEPTIDE MIMETICS OF THE HIV-1 GP41 PRE-HAIRPIN INTERMEDIATE | NGLY1, FURIN, CD4 | MEN1 597/4885LMNA 423/4885KMT2A 4199/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.