Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | PAX8 | Q06710 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | GPX4 | P36969 | 1/20 | 0.49 |
| ▸ | JAK2 | O60674 | 1/20 | 0.48 |
| ▸ | LTB4R2 | Q9NPC1 | 2/20 | 0.46 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.42 |
| ▸ | PTPN11 | Q06124 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.41 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | NOS3 | P29474 | 1/20 | 0.40 |
| ▸ | NOS1 | P29475 | 1/20 | 0.40 |
| ▸ | NOS2 | P35228 | 1/20 | 0.40 |
| ▸ | KDM5A | P29375 | 1/20 | 0.40 |
| ▸ | PTGES | O14684 | 1/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6064774 | 0.96 | LTB4R2 (0.46) | NPC1RAB9APAX8ALDH1A1TP53 | |
| SCHEMBL15020737 | 0.84 | PLA2G2A (0.45) | NPC1RAB9APAX8ALDH1A1TP53 | |
| SCHEMBL3055011 | 0.84 | NPC1 (0.65) | NPC1RAB9APAX8ALDH1A1TP53 | |
| SCHEMBL5058794 | 0.82 | NPC1 (0.49) | NPC1RAB9APAX8ALDH1A1TP53 | |
| SCHEMBL11344796 | 0.82 | NPC1 (0.68) | NPC1RAB9APAX8ALDH1A1TP53 | |
| SCHEMBL1082836 | 0.82 | NPC1 (0.68) | NPC1RAB9APAX8ALDH1A1TP53 | |
| SCHEMBL7096422 | 0.82 | NPC1 (0.68) | NPC1RAB9APAX8ALDH1A1TP53 | |
| SCHEMBL4024848 | 0.82 | NPC1 (0.68) | NPC1RAB9APAX8ALDH1A1TP53 | |
| SCHEMBL11344801 | 0.82 | NPC1 (0.68) | NPC1RAB9APAX8ALDH1A1TP53 | |
| SCHEMBL6424475 | 0.82 | NPC1 (0.68) | NPC1RAB9APAX8ALDH1A1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1497263-B1 | ACYL-3-CARBOXYPHENYLUREA DERIVATIVES, METHOD FOR PRODUCTION AND USE THEREOF | SANOFI AVENTIS DEUTSCHLAND (DE) | 2008-08-13 | — | — | EP | disclosed |
| EP-1884513-A1 | PYRAZOLE COMPOUND AND THERAPEUTIC AGENT FOR DIABETES COMPRISING THE SAME | Japan Tobacco, Inc. (JP) | 2008-02-06 | — | — | EP | disclosed |
| US-20070032529-A1 | Pyrazole compounds and their use as antidiabetes agents | JAPAN TOBACCO INC. (JP) | 2007-02-08 | — | — | US | disclosed |
| US-7078404-B2 | Acyl-3-carboxyphenylurea derivatives, processes for preparing them and their use | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2006-07-18 | — | — | US | disclosed |
| US-7078404-B2 | Acyl-3-carboxyphenylurea derivatives, processes for preparing them and their use | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2006-07-18 | — | — | US | disclosed |
| US-7078404-B2 | Acyl-3-carboxyphenylurea derivatives, processes for preparing them and their use | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2006-07-18 | — | — | US | disclosed |
| CN-1263734-C | Acyl-3-carboxyphenylurea derivatives, method for production and use thereof | SANOFI AVENTIS PHARMA GMBH (DE) | 2006-07-12 | — | — | CN | disclosed |
| CN-1263734-C | Acyl-3-carboxyphenylurea derivatives, method for production and use thereof | SANOFI AVENTIS PHARMA GMBH (DE) | 2006-07-12 | — | — | CN | disclosed |
| CN-1646486-A | Acyl-3-carboxyphenylurea derivatives, method for production and use thereof | AVENTIS PHARMA GMBH (DE) | 2005-07-27 | — | — | CN | disclosed |
| CN-1646486-A | Acyl-3-carboxyphenylurea derivatives, method for production and use thereof | AVENTIS PHARMA GMBH (DE) | 2005-07-27 | — | — | CN | disclosed |
| EP-1497263-A1 | ACYL-3-CARBOXYPHENYLUREA DERIVATIVES, METHOD FOR PRODUCTION AND USE THEREOF | Aventis Pharma Deutschland GmbH (DE) | 2005-01-19 | — | — | EP | disclosed |
| US-20030216370-A1 | Acyl-3-carboxyphenylurea derivatives, processes for preparing them and their use | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2003-11-20 | — | — | US | disclosed |
| US-20030216370-A1 | Acyl-3-carboxyphenylurea derivatives, processes for preparing them and their use | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2003-11-20 | — | — | US | disclosed |
| US-20030216370-A1 | Acyl-3-carboxyphenylurea derivatives, processes for preparing them and their use | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2003-11-20 | — | — | US | disclosed |
| WO-2003084923-A1 | ACYL-3-CARBOXYPHENYLUREA DERIVATIVES, METHOD FOR PRODUCTION AND USE THEREOF | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2003-10-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030216370-A1 | Acyl-3-carboxyphenylurea derivatives, processes for preparing them and their use | CPS1, AGPAT2, GLS | NPC1 1546/4885RAB9A 3183/4885PAX8 4639/4885 |
| US-20070032529-A1 | Pyrazole compounds and their use as antidiabetes agents | PYGL, GYS2, AGL | NPC1 2838/4885RAB9A 2748/4885PAX8 2414/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.