Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.74 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.74 |
| ▸ | NPC1 | O15118 | 5/20 | 0.74 |
| ▸ | RAB9A | P51151 | 5/20 | 0.74 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.74 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.74 |
| ▸ | HPGD | P15428 | 4/20 | 0.74 |
| ▸ | MAPT | P10636 | 4/20 | 0.74 |
| ▸ | MAOA | P21397 | 4/20 | 0.74 |
| ▸ | MAOB | P27338 | 4/20 | 0.74 |
| ▸ | TP53 | P04637 | 3/20 | 0.74 |
| ▸ | ALDH2 | P05091 | 3/20 | 0.74 |
| ▸ | CA12 | O43570 | 2/20 | 0.74 |
| ▸ | LMNA | P02545 | 2/20 | 0.74 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.74 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.74 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.74 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.74 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.74 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.74 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18575851 | 0.92 | ALDH2 (0.70) | KDM4EALDH1A1NPC1RAB9AHSD17B10 | |
| SCHEMBL12238031 | 0.88 | KDM4E (0.72) | KDM4EALDH1A1NPC1RAB9AHSD17B10 | |
| SCHEMBL30527934 | 0.86 | EGFR (0.66) | KDM4EALDH1A1NPC1RAB9AHSD17B10 | |
| SCHEMBL29085508 | 0.86 | EGFR (0.66) | KDM4EALDH1A1NPC1RAB9AHSD17B10 | |
| Daidzein SCHEMBL29374778 | 0.86 | KDM4E (1.00) | KDM4EALDH1A1NPC1RAB9AHSD17B10 | |
| Daidzein SCHEMBL21114371 | 0.86 | KDM4E (1.00) | KDM4EALDH1A1NPC1RAB9AHSD17B10 | |
| Daidzein SCHEMBL19814 | 0.86 | KDM4E (1.00) | KDM4EALDH1A1NPC1RAB9AHSD17B10 | |
| SCHEMBL10563812 | 0.85 | ALOX12 (0.73) | KDM4EALDH1A1NPC1RAB9AHSD17B10 | |
| SCHEMBL12489984 | 0.84 | XDH (0.70) | KDM4EALDH1A1NPC1RAB9AHSD17B10 | |
| SCHEMBL10624565 | 0.82 | MAPT (0.75) | KDM4EALDH1A1NPC1RAB9AHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108264506-B | Isoflavone derivative, preparation method and medical application thereof | 中国药科大学 | 2021-01-26 | — | — | CN | disclosed |
| CN-104672192-A | Derivatives of isoflavones amides, as well as preparation method and medical application of derivatives | UNIV CHINA PHARMA | 2015-06-03 | — | — | CN | disclosed |
| EP-2751090-A1 | ALDH-2 INHIBITORS IN THE TREATMENT OF ADDICTION | Gilead Sciences, Inc. (US) | 2014-07-09 | — | — | EP | disclosed |
| CN-103764640-A | ALDH-2 inhibitors in the treatment of addiction | GILEAD SCIENCES INC | 2014-04-30 | — | — | CN | disclosed |
| US-8673966-B2 | ALDH-2 inhibitors in the treatment of addiction | GILEAD SCIENCES, INC. (US) | 2014-03-18 | — | — | US | disclosed |
| US-8673966-B2 | ALDH-2 inhibitors in the treatment of addiction | GILEAD SCIENCES, INC. (US) | 2014-03-18 | — | — | US | disclosed |
| US-20130231325-A1 | ALDH-2 INHIBITORS IN THE TREATMENT OF ADDICTION | GILEAD SCIENCES. INC. (US) | 2013-09-05 | — | — | US | disclosed |
| US-20130231325-A1 | ALDH-2 INHIBITORS IN THE TREATMENT OF ADDICTION | GILEAD SCIENCES. INC. (US) | 2013-09-05 | — | — | US | disclosed |
| WO-2013033377-A1 | ALDH-2 INHIBITORS IN THE TREATMENT OF ADDICTION | GILEAD SCIENCES, INC. (US) | 2013-03-07 | — | — | WO | disclosed |
| WO-2011133728-A2 | ANTI-VIRAL COMPOUNDS | Kineta, Inc. (US) | 2011-10-27 | — | — | WO | disclosed |
| EP-1542675-A4 | COMPOUNDS USEFUL FOR THE INHIBITION OF ALDH | ENDOWMENT FOR RES IN HUMAN BIO (US) | 2008-11-19 | — | — | EP | disclosed |
| US-7368434-B2 | Compounds useful for the inhibition of ALDH | THE ENDOWMENT FOR RESEARCH IN HUMAN BIOLOGY, INC. (US) | 2008-05-06 | — | — | US | disclosed |
| EP-1542675-A1 | COMPOUNDS USEFUL FOR THE INHIBITION OF ALDH | The Endowment For Research In Human Biology, Inc. (US) | 2005-06-22 | — | — | EP | disclosed |
| US-20040068003-A1 | Compounds useful for the inhibition of ALDH | THE ENDOWMENT FOR RESEARCH IN HUMAN BIOLOGY, INC, | 2004-04-08 | — | — | US | disclosed |
| WO-2004002470-A1 | COMPOUNDS USEFUL FOR THE INHIBITION OF ALDH | THE ENDOWMENT FOR RESEARCH IN HUMAN BIOLOGY, INC. (US) | 2004-01-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040068003-A1 | Compounds useful for the inhibition of ALDH | ALDH2, ALDH1A1, ALDH3A1 | KDM4E 1630/4885ALDH1A1 2/4885NPC1 2290/4885 |
| US-20130231325-A1 | ALDH-2 INHIBITORS IN THE TREATMENT OF ADDICTION | ALDH1A1, ADH1A, ALDH1B1 | KDM4E 1604/4885ALDH1A1 1/4885NPC1 2357/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.