Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL3 | Q96JM7 | 11/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 11/20 | 0.46 |
| ▸ | MBTD1 | Q05BQ5 | 4/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 7/20 | 0.39 |
| ▸ | TP53BP1 | Q12888 | 4/20 | 0.36 |
| ▸ | L3MBTL4 | Q8NA19 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5170255 | 0.83 | NPC1 (0.34) | — | |
| SCHEMBL467489 | 0.70 | PIM1 (0.36) | L3MBTL3L3MBTL1MBTD1HRH3ALDH1A1 | |
| SCHEMBL2480167 | 0.69 | HRH3 (0.36) | L3MBTL3L3MBTL1HRH3ALDH1A1 | |
| SCHEMBL467680 | 0.69 | KCNH2 (0.38) | L3MBTL3L3MBTL1ALDH1A1KCNH2 | |
| SCHEMBL2485210 | 0.68 | KMT2A (0.33) | HRH3 | |
| SCHEMBL6687902 | 0.67 | L3MBTL3 (0.47) | L3MBTL3L3MBTL1MBTD1HRH3TP53BP1 | |
| SCHEMBL23682775 | 0.64 | L3MBTL3 (1.00) | L3MBTL3L3MBTL1MBTD1TP53BP1L3MBTL4 | |
| SCHEMBL4257753 | 0.62 | L3MBTL1 (0.50) | L3MBTL3L3MBTL1MBTD1HRH3ALDH1A1 | |
| SCHEMBL1901744 | 0.61 | — | — | |
| SCHEMBL14528663 | 0.61 | L3MBTL3 (0.73) | L3MBTL3L3MBTL1MBTD1HRH3TP53BP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2387395-A1 | AXL INHIBITORS FOR USE IN COMBINATION THERAPY FOR PREVENTING, TREATING OR MANAGING METASTATIC CANCER | Rigel Pharmaceuticals, Inc. (US) | 2011-11-23 | — | — | EP | disclosed |
| US-8040491-B2 | Exposure method, substrate stage, exposure apparatus, and device manufacturing method | NIKON CORPORATION (JP) | 2011-10-18 | — | — | US | disclosed |