Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.33 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2480167 | 0.94 | HRH3 (0.36) | HRH3GAA | |
| SCHEMBL467489 | 0.88 | PIM1 (0.36) | HRH3 | |
| SCHEMBL1385856 | 0.79 | ADRA2C (0.33) | KMT2AHRH3GAA | |
| SCHEMBL2483016 | 0.78 | GPR119 (0.30) | — | |
| SCHEMBL2482791 | 0.76 | CASP1 (0.34) | — | |
| SCHEMBL2480845 | 0.75 | KDM4E (0.39) | HRH3GAA | |
| SCHEMBL2477477 | 0.72 | NPSR1 (0.43) | KMT2AMEN1 | |
| SCHEMBL2482995 | 0.71 | MEN1 (0.39) | KMT2AMEN1GAA | |
| SCHEMBL467680 | 0.71 | KCNH2 (0.38) | — | |
| SCHEMBL468653 | 0.68 | L3MBTL3 (0.46) | HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2376493-A1 | DIHYDROPYRIMIDOPYRIMIDINE DERIVATIVE | MSD K.K. (JP) | 2011-10-19 | — | — | EP | disclosed |
| WO-2010067886-A1 | DIHYDROPYRIMIDOPYRIMIDINE DERIVATIVE | BANYU PHARMACEUTICAL CO.,LTD. (JP) | 2010-06-17 | — | — | WO | disclosed |