Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | VCP | P55072 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
| ▸ | ACVR1 | Q04771 | 8/20 | 0.33 |
| ▸ | L3MBTL3 | Q96JM7 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.31 |
| ▸ | MELK | Q14680 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL467489 | 0.84 | PIM1 (0.36) | KCNH2ALDH1A1VCPPIM1ACVR1 | |
| SCHEMBL1903288 | 0.79 | TSHR (0.35) | ALDH1A1 | |
| SCHEMBL1901744 | 0.72 | — | — | |
| SCHEMBL2485210 | 0.71 | KMT2A (0.33) | — | |
| SCHEMBL468653 | 0.69 | L3MBTL3 (0.46) | KCNH2ALDH1A1L3MBTL3L3MBTL1 | |
| SCHEMBL2480167 | 0.69 | HRH3 (0.36) | ALDH1A1L3MBTL3L3MBTL1 | |
| SCHEMBL467582 | 0.68 | KDM4E (0.38) | ALDH1A1 | |
| SCHEMBL1385856 | 0.66 | ADRA2C (0.33) | ALDH1A1 | |
| SCHEMBL3436969 | 0.66 | L3MBTL1 (0.46) | ALDH1A1VCPPIM1ACVR1L3MBTL3 | |
| SCHEMBL25511926 | 0.65 | PIM1 (0.40) | KCNH2ALDH1A1VCPPIM1ACVR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2387395-A1 | AXL INHIBITORS FOR USE IN COMBINATION THERAPY FOR PREVENTING, TREATING OR MANAGING METASTATIC CANCER | Rigel Pharmaceuticals, Inc. (US) | 2011-11-23 | — | — | EP | disclosed |
| US-8040491-B2 | Exposure method, substrate stage, exposure apparatus, and device manufacturing method | NIKON CORPORATION (JP) | 2011-10-18 | — | — | US | disclosed |