Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | ACVR1 | Q04771 | 10/20 | 0.34 |
| ▸ | VCP | P55072 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.33 |
| ▸ | L3MBTL3 | Q96JM7 | 3/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | MBTD1 | Q05BQ5 | 1/20 | 0.31 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.30 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.30 |
| ▸ | ACVR1B | P36896 | 1/20 | 0.30 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | RAD52 | P43351 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2485210 | 0.88 | KMT2A (0.33) | HRH3 | |
| SCHEMBL2480167 | 0.85 | HRH3 (0.36) | ALDH1A1L3MBTL1L3MBTL3HRH3 | |
| SCHEMBL1385856 | 0.84 | ADRA2C (0.33) | ALDH1A1HRH3KDM4E | |
| SCHEMBL467680 | 0.84 | KCNH2 (0.38) | PIM1ALDH1A1ACVR1VCPL3MBTL1 | |
| SCHEMBL2483016 | 0.76 | GPR119 (0.30) | — | |
| SCHEMBL468653 | 0.70 | L3MBTL3 (0.46) | ALDH1A1L3MBTL1L3MBTL3HRH3KCNH2 | |
| SCHEMBL2477492 | 0.69 | ADRB1 (0.40) | — | |
| SCHEMBL2482791 | 0.69 | CASP1 (0.34) | ACHE | |
| SCHEMBL2480845 | 0.67 | KDM4E (0.39) | ALDH1A1HRH3KDM4E | |
| SCHEMBL13616253 | 0.67 | L3MBTL3 (0.59) | ALDH1A1VCPL3MBTL1L3MBTL3MBTD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2387395-A1 | AXL INHIBITORS FOR USE IN COMBINATION THERAPY FOR PREVENTING, TREATING OR MANAGING METASTATIC CANCER | Rigel Pharmaceuticals, Inc. (US) | 2011-11-23 | — | — | EP | disclosed |
| US-8040491-B2 | Exposure method, substrate stage, exposure apparatus, and device manufacturing method | NIKON CORPORATION (JP) | 2011-10-18 | — | — | US | disclosed |