SCHEMBL4759546

SCHEMBL4759546

CCCCOC(=O)NC(CC(=O)O)c1cc(C)n(C)n1

nearest known ligand 0.37

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 4/20 0.37
L3MBTL1 Q9Y468 2/20 0.37
MAPK1 P28482 2/20 0.37
ALDH1A1 P00352 1/20 0.36
GLA P06280 1/20 0.36
KMT2A Q03164 1/20 0.36
HPGD P15428 4/20 0.36
RAB9A P51151 4/20 0.36
NPC1 O15118 3/20 0.36
CYP1A2 P05177 2/20 0.36
CYP2C9 P11712 2/20 0.36
CYP2C19 P33261 2/20 0.36
CYP26A1 O43174 1/20 0.35
TSHR P16473 1/20 0.35
CTSK P43235 1/20 0.35
LMNA P02545 1/20 0.34
FAAH O00519 1/20 0.34
HRH3 Q9Y5N1 4/20 0.34
HRH4 Q9H3N8 2/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5500079 0.78 L3MBTL1 (0.40) SMN1; SMN2L3MBTL1MAPK1HPGDRAB9A
SCHEMBL4759543 0.75 ITGB3 (0.40) SMN1; SMN2L3MBTL1MAPK1ALDH1A1GLA
SCHEMBL3663114 0.74 L3MBTL1 (0.43) SMN1; SMN2L3MBTL1MAPK1ALDH1A1HPGD
SCHEMBL5086318 0.74 FAAH (0.45) SMN1; SMN2L3MBTL1MAPK1ALDH1A1KMT2A
SCHEMBL4686872 0.74 HRH3 (0.39) SMN1; SMN2L3MBTL1HPGDRAB9ANPC1
SCHEMBL6015437 0.74 ESR1 (0.41) SMN1; SMN2L3MBTL1MAPK1ALDH1A1GLA
SCHEMBL5085765 0.73 SMN1; SMN2 (0.50) SMN1; SMN2L3MBTL1MAPK1HPGDRAB9A
SCHEMBL844472 0.73 SMN1; SMN2 (0.57) SMN1; SMN2L3MBTL1MAPK1ALDH1A1HPGD
SCHEMBL14040614 0.73 SMN1; SMN2 (0.57) SMN1; SMN2L3MBTL1MAPK1ALDH1A1HPGD
SCHEMBL5085784 0.72 CYP26A1 (0.53) SMN1; SMN2L3MBTL1MAPK1HPGDRAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1981854-A1 ARYLPROPIONAMIDE, ARYLACRYLAMIDE, ARYLPROPYNAMIDE, OR ARYLMETHYLUREA ANALOGS AS FACTOR XIA INHIBITORS Brystol-Myers Squibb Company (US) 2008-10-22 EP disclosed
WO-2007070826-A1 ARYLPROPIONAMIDE, ARYLACRYLAMIDE, ARYLPROPYNAMIDE, OR ARYLMETHYLUREA ANALOGS AS FACTOR XIA INHIBITORS BRISTOL-MYERS SQUIBB COMPANY (US) 2007-06-21 WO disclosed