Known targets — ChEMBL curated mechanism
CHRM1CHRM2CHRM3CHRM4CHRM5SLC6A2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TERT | O14746 | 1/20 | 0.46 |
| ▸ | CHAT | P28329 | 3/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 7/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | NPC1 | O15118 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | USP2 | O75604 | 3/20 | 0.40 |
| ▸ | GPR55 | Q9Y2T6 | 2/20 | 0.40 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.40 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL372527 | 0.85 | CHAT (0.61) | TERTCHATPTGS2RAB9AKMT2A | |
| SCHEMBL10841638 | 0.84 | RAB9A (0.47) | TERTCHATPTGS2RAB9AKMT2A | |
| SCHEMBL11398927 | 0.84 | CYP2A6 (0.47) | TERTCHATPTGS2RAB9AKMT2A | |
| SCHEMBL7044936 | 0.84 | CYP2A6 (0.47) | TERTCHATPTGS2RAB9AKMT2A | |
| SCHEMBL10844389 | 0.84 | PABPC1 (0.58) | TERTPTGS2KMT2ANPC1POLB | |
| SCHEMBL8987883 | 0.83 | TERT (0.50) | TERTPTGS2KMT2ANPC1MEN1 | |
| SCHEMBL4688796 | 0.83 | TERT (0.43) | TERTCHATPTGS2RAB9AKMT2A | |
| SCHEMBL531126 | 0.81 | MEN1 (0.63) | TERTRAB9AKMT2ANPC1MEN1 | |
| SCHEMBL531127 | 0.81 | MEN1 (0.63) | TERTRAB9AKMT2ANPC1MEN1 | |
| SCHEMBL7047125 | 0.80 | CYP2A6 (0.48) | TERTCHATPTGS2RAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0068880-B1 | PHOTOGRAPHIC ELEMENTS CAPABLE OF PROVIDING OXOINDOLIZINE AND OXOINDOLIZINIUM DYE COMPOUNDS | EASTMAN KODAK COMPANY (a New Jersey corporation) (US) | 1985-08-07 | — | — | EP | disclosed |
| EP-0068876-B1 | OXOINDOLIZINE AND OXOINDOLIZINIUM DYES AND PROCESSES FOR THEIR PREPARATION | EASTMAN KODAK COMPANY (a New Jersey corporation) (US) | 1985-04-03 | — | — | EP | disclosed |
| US-4368247-A | Photographic materials and processes comprising oxoindolizine and oxoindolizinium compounds | EASTMAN KODAK COMPANY (US) | 1983-01-11 | — | — | US | disclosed |
| EP-0068876-A1 | Oxoindolizine and oxoindolizinium dyes and processes for their preparation | EASTMAN KODAK COMPANY (a New Jersey corporation) (US) | 1983-01-05 | — | — | EP | disclosed |
| EP-0068880-A1 | Photographic elements capable of providing oxoindolizine and oxoindolizinium dye compounds | EASTMAN KODAK COMPANY (a New Jersey corporation) (US) | 1983-01-05 | — | — | EP | disclosed |