Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 7/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 7/20 | 0.37 |
| ▸ | PYGL | P06737 | 1/20 | 0.37 |
| ▸ | ADH1A | P07327 | 1/20 | 0.37 |
| ▸ | KIT | P10721 | 1/20 | 0.37 |
| ▸ | FLT1 | P17948 | 1/20 | 0.37 |
| ▸ | FLT4 | P35916 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | ABL2 | P42684 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | EDNRA | P25101 | 1/20 | 0.36 |
| ▸ | APP | P05067 | 1/20 | 0.35 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17413316 | 0.94 | NPC1 (0.38) | NPC1RAB9AKDM1ARCOR1EGFR | |
| SCHEMBL10111995 | 0.94 | NPC1 (0.40) | NPC1RAB9AKDM1ARCOR1EGFR | |
| SCHEMBL15493888 | 0.91 | PYGL (0.36) | NPC1RAB9AKDM1ARCOR1EGFR | |
| SCHEMBL10111909 | 0.91 | NPC1 (0.42) | NPC1RAB9AKDM1ARCOR1EGFR | |
| SCHEMBL15047618 | 0.91 | EGFR (0.41) | NPC1RAB9AKDM1ARCOR1EGFR | |
| SCHEMBL13669002 | 0.90 | MMP13 (0.40) | NPC1RAB9AKDM1ARCOR1EGFR | |
| SCHEMBL22512603 | 0.90 | NPC1 (0.46) | NPC1RAB9AKDM1ARCOR1EGFR | |
| SCHEMBL468987 | 0.89 | ADH1A (0.37) | NPC1RAB9AKDM1ARCOR1EGFR | |
| SCHEMBL15047620 | 0.89 | NPC1 (0.38) | NPC1RAB9AKDM1ARCOR1EGFR | |
| SCHEMBL22512600 | 0.88 | EGFR (0.42) | NPC1RAB9AKDM1ARCOR1EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8288557-B2 | Bivalent linkers and conjugates thereof | ENDOCYTE, INC. (US) | 2012-10-16 | — | — | US | disclosed |
| US-8288557-B2 | Bivalent linkers and conjugates thereof | ENDOCYTE, INC. (US) | 2012-10-16 | — | — | US | disclosed |
| US-20120065149-A1 | Vitamin receptor binding drug delivery conjugates | VLAHOV IONTCHO R (US) | 2012-03-15 | — | — | US | disclosed |
| US-20090203889-A1 | Bivalent linkers and conjugates thereof | ENDOCYTE, INC. (US) | 2009-08-13 | — | — | US | disclosed |
| US-20090203889-A1 | Bivalent linkers and conjugates thereof | ENDOCYTE, INC. (US) | 2009-08-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090203889-A1 | Bivalent linkers and conjugates thereof | CCNB2, PAICS, FOLR2 | NPC1 3587/4885RAB9A 2353/4885KDM1A 2583/4885 |
| US-20120065149-A1 | Vitamin receptor binding drug delivery conjugates | VDR, CYP2R1, CYP24A1 | NPC1 1188/4885RAB9A 2572/4885KDM1A 3224/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.