SCHEMBL4691641

SCHEMBL4691641

Cc1ccc(C(CC(N)=O)N2CC3CN(C(=O)c4ccoc4)CC3C2)cc1Cl

nearest known ligand 0.43

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
CHRNB2 P17787 1/20 0.43
CHRNB4 P30926 1/20 0.43
CHRNA3 P32297 1/20 0.43
CHRNA7 P36544 1/20 0.43
CHRNA4 P43681 1/20 0.43
CCR5 P51681 2/20 0.39
ALDH1A1 P00352 2/20 0.38
HPGD P15428 1/20 0.36
KMT2A Q03164 3/20 0.35
MEN1 O00255 2/20 0.35
TNF P01375 1/20 0.35
POLB P06746 1/20 0.35
HCRTR1 O43613 1/20 0.33
HCRTR2 O43614 1/20 0.33
CHRM2 P08172 1/20 0.33
CHRM3 P20309 1/20 0.33
L3MBTL1 Q9Y468 1/20 0.32
EPHA2 P29317 1/20 0.32
KDR P35968 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4695972 0.86 CHRNB2 (0.40) CHRNB2CHRNB4CHRNA3CHRNA7CHRNA4
SCHEMBL4692725 0.84 CHRNA4 (0.47) CHRNB2CHRNB4CHRNA3CHRNA7CHRNA4
SCHEMBL4689519 0.83 ALDH1A1 (0.47) CHRNB2CHRNB4CHRNA3CHRNA7CHRNA4
SCHEMBL4694328 0.83 TNF (0.35) ALDH1A1HPGDKMT2AMEN1TNF
SCHEMBL4692070 0.83 HPGD (0.36) CCR5ALDH1A1HPGDTNF
SCHEMBL4691760 0.83 KMT2A (0.47) CHRNB2CHRNB4CHRNA3CHRNA7CHRNA4
SCHEMBL3281863 0.83 HCRTR1 (0.48) CCR5TNFHCRTR1HCRTR2
SCHEMBL4694334 0.83 HCRTR1 (0.43) CCR5TNFHCRTR1HCRTR2
SCHEMBL4690403 0.83 HCRTR1 (0.39) CCR5ALDH1A1HPGDTNFHCRTR1
SCHEMBL4690534 0.83 LMNA (0.39) HPGDKMT2ATNFL3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1761542-B1 OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS HOFFMANN LA ROCHE (CH) 2008-01-02 EP claimed
EP-1761542-A2 OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS F.HOFFMANN-LA ROCHE AG (CH) 2007-03-14 EP claimed
WO-2005121145-A2 OCTAHYDRO-PYRROLO[3,4-C] DERIVATIVES AND THEIR USE AS ANTIVIRAL COMPOUNDS F. HOFFMANN-LA ROCHE AG (CH) 2005-12-22 WO claimed
EP-1761542-B1 OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS HOFFMANN LA ROCHE (CH) 2008-01-02 EP disclosed