SCHEMBL4695972

SCHEMBL4695972

Cc1ccc(C(CC(N)=O)N2CC3CN(C(=O)c4ccncc4)CC3C2)cc1Cl

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRNB2 P17787 2/20 0.40
CHRNB4 P30926 2/20 0.40
CHRNA3 P32297 2/20 0.40
CHRNA4 P43681 2/20 0.40
CHRNA7 P36544 1/20 0.40
GAA P10253 1/20 0.39
NPC1 O15118 1/20 0.38
KMT2A Q03164 1/20 0.38
TNF P01375 1/20 0.37
HCRTR1 O43613 2/20 0.36
HCRTR2 O43614 2/20 0.36
HPGD P15428 1/20 0.36
RECQL P46063 1/20 0.36
ALDH1A1 P00352 2/20 0.35
CYP2D6 P10635 2/20 0.35
CYP3A4 P08684 1/20 0.35
KDM4E B2RXH2 1/20 0.35
POLB P06746 1/20 0.35
GFER P55789 1/20 0.35
MAP3K14 Q99558 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4693218 0.90 CHRNB2 (0.45) CHRNB2CHRNB4CHRNA3CHRNA4CHRNA7
SCHEMBL4690843 0.89 GAA (0.41) GAAKMT2AHPGDCYP3A4
SCHEMBL4693625 0.89 HCRTR1 (0.37) TNFHCRTR1HCRTR2HPGDALDH1A1
SCHEMBL4691396 0.89 HCRTR1 (0.39) TNFHCRTR1HCRTR2POLB
SCHEMBL4696341 0.89 HCRTR1 (0.37) NPC1TNFHCRTR1HCRTR2
SCHEMBL4692070 0.88 HPGD (0.36) NPC1TNFHPGDALDH1A1
SCHEMBL4689519 0.88 ALDH1A1 (0.47) CHRNB2CHRNB4CHRNA3CHRNA4CHRNA7
SCHEMBL4690534 0.87 LMNA (0.39) KMT2ATNFHPGDCYP3A4
SCHEMBL4693590 0.87 KDM1A (0.48) ALDH1A1
SCHEMBL4694328 0.86 TNF (0.35) KMT2ATNFHCRTR1HCRTR2HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1761542-B1 OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS HOFFMANN LA ROCHE (CH) 2008-01-02 EP claimed
EP-1761542-A2 OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS F.HOFFMANN-LA ROCHE AG (CH) 2007-03-14 EP claimed
WO-2005121145-A2 OCTAHYDRO-PYRROLO[3,4-C] DERIVATIVES AND THEIR USE AS ANTIVIRAL COMPOUNDS F. HOFFMANN-LA ROCHE AG (CH) 2005-12-22 WO claimed
EP-1761542-B1 OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS HOFFMANN LA ROCHE (CH) 2008-01-02 EP disclosed