Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 2/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | DRD2 | P14416 | 3/20 | 0.47 |
| ▸ | DRD4 | P21917 | 3/20 | 0.47 |
| ▸ | DRD3 | P35462 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | CCR3 | P51677 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | DRD1 | P21728 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4690504 | 0.93 | HCRTR1 (0.50) | F10CYP2C9CYP2D6DRD2DRD4 | |
| SCHEMBL4694269 | 0.91 | HCRTR1 (0.48) | F10DRD2DRD4DRD3KMT2A | |
| SCHEMBL4690666 | 0.89 | NTRK1 (0.44) | F10DRD2DRD4DRD3KMT2A | |
| SCHEMBL4695945 | 0.87 | NTRK1 (0.44) | F10CYP2C9DRD2DRD4DRD3 | |
| SCHEMBL4691874 | 0.86 | ALDH1A1 (0.43) | CYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL4690744 | 0.86 | NTRK1 (0.42) | F10DRD2DRD4KMT2AMEN1 | |
| SCHEMBL4691666 | 0.86 | CCR3 (0.47) | F10CYP2C9CYP2D6DRD2DRD4 | |
| SCHEMBL4693332 | 0.84 | SLC6A4 (0.45) | DRD2DRD4DRD3SMN1; SMN2 | |
| SCHEMBL4691218 | 0.83 | DRD2 (0.45) | CYP2C9CYP2D6DRD2DRD4DRD3 | |
| SCHEMBL4691761 | 0.83 | SLC6A2 (0.44) | DRD2DRD4DRD3KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1761542-B1 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | HOFFMANN LA ROCHE (CH) | 2008-01-02 | — | — | EP | claimed |
| EP-1761542-A2 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | F.HOFFMANN-LA ROCHE AG (CH) | 2007-03-14 | — | — | EP | claimed |
| WO-2005121145-A2 | OCTAHYDRO-PYRROLO[3,4-C] DERIVATIVES AND THEIR USE AS ANTIVIRAL COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-12-22 | — | — | WO | claimed |
| EP-1761542-B1 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | HOFFMANN LA ROCHE (CH) | 2008-01-02 | — | — | EP | disclosed |