SCHEMBL4691874

SCHEMBL4691874

COc1ccc(Cl)cc1C(=O)N1CC2CN(CCCNc3ccc(C)c(Cl)c3)CC2C1

nearest known ligand 0.45

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.43
KDM4E B2RXH2 3/20 0.43
HCRTR1 O43613 2/20 0.43
HCRTR2 O43614 2/20 0.43
KCNK3 O14649 1/20 0.42
KCNK9 Q9NPC2 1/20 0.42
LMNA P02545 1/20 0.42
GAA P10253 1/20 0.41
MAPT P10636 1/20 0.41
CYP1A2 P05177 1/20 0.40
CYP2C9 P11712 1/20 0.40
CYP2C19 P33261 1/20 0.40
DUSP3 P51452 1/20 0.40
PTPN5 P54829 1/20 0.40
PTPN11 Q06124 1/20 0.40
ADRA1D P25100 2/20 0.39
ADRA1A P35348 2/20 0.39
ADRA1B P35368 2/20 0.39
HTR1A P08908 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4690506 0.93 HCRTR1 (0.52) ALDH1A1HCRTR1HCRTR2KCNK3KCNK9
SCHEMBL4691840 0.93 MAPT (0.47) ALDH1A1HCRTR1HCRTR2LMNAGAA
SCHEMBL4694353 0.92 KCNK3 (0.46) ALDH1A1HCRTR1HCRTR2KCNK3KCNK9
SCHEMBL4694270 0.91 HCRTR1 (0.50) ALDH1A1KDM4EHCRTR1HCRTR2KCNK3
SCHEMBL4691406 0.90 HCRTR1 (0.48) ALDH1A1HCRTR1HCRTR2KCNK3KCNK9
SCHEMBL4692694 0.90 LMNA (0.46) ALDH1A1KDM4EHCRTR1HCRTR2KCNK3
SCHEMBL4690682 0.88 P2RX7 (0.44) ALDH1A1HCRTR1HCRTR2LMNAGAA
SCHEMBL4690670 0.88 UBE2M (0.44) ALDH1A1KDM4EHCRTR1HCRTR2LMNA
SCHEMBL4695902 0.88 HCRTR2 (0.48) ALDH1A1HCRTR1HCRTR2GAAMAPT
SCHEMBL4695946 0.87 HCRTR1 (0.43) ALDH1A1KDM4EHCRTR1HCRTR2LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1761542-B1 OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS HOFFMANN LA ROCHE (CH) 2008-01-02 EP claimed
EP-1761542-A2 OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS F.HOFFMANN-LA ROCHE AG (CH) 2007-03-14 EP claimed
WO-2005121145-A2 OCTAHYDRO-PYRROLO[3,4-C] DERIVATIVES AND THEIR USE AS ANTIVIRAL COMPOUNDS F. HOFFMANN-LA ROCHE AG (CH) 2005-12-22 WO claimed
EP-1761542-B1 OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS HOFFMANN LA ROCHE (CH) 2008-01-02 EP disclosed