Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 16/20 | 0.44 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.38 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4694466 | 0.93 | RIPK2 (0.50) | MAPK14RIPK2LMNARAB9ASMN1; SMN2 | |
| SCHEMBL4692257 | 0.89 | PDK1 (0.43) | MAPK14LMNASMN1; SMN2HCRTR1HCRTR2 | |
| SCHEMBL4694271 | 0.82 | KDM4E (0.39) | LMNASMN1; SMN2HCRTR1HCRTR2 | |
| SCHEMBL4692888 | 0.79 | MAPK14 (0.49) | MAPK14RIPK2HCRTR1HCRTR2 | |
| SCHEMBL4690551 | 0.79 | MAPK14 (0.41) | MAPK14RIPK2LMNARAB9ASMN1; SMN2 | |
| SCHEMBL4694309 | 0.78 | HCRTR1 (0.39) | HCRTR1HCRTR2 | |
| SCHEMBL4691301 | 0.77 | HCRTR1 (0.44) | LMNAHCRTR1HCRTR2 | |
| SCHEMBL4689903 | 0.77 | P2RX7 (0.41) | MAPK14LMNARAB9A | |
| SCHEMBL4691673 | 0.77 | HCRTR1 (0.38) | HCRTR1HCRTR2 | |
| SCHEMBL4691928 | 0.77 | MAPK1 (0.41) | SMN1; SMN2HCRTR1HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1761542-B1 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | HOFFMANN LA ROCHE (CH) | 2008-01-02 | — | — | EP | claimed |
| EP-1761542-A2 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | F.HOFFMANN-LA ROCHE AG (CH) | 2007-03-14 | — | — | EP | claimed |
| WO-2005121145-A2 | OCTAHYDRO-PYRROLO[3,4-C] DERIVATIVES AND THEIR USE AS ANTIVIRAL COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-12-22 | — | — | WO | claimed |
| EP-1761542-B1 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | HOFFMANN LA ROCHE (CH) | 2008-01-02 | — | — | EP | disclosed |