Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | APEX1 | P27695 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | YAP1 | P46937 | 1/20 | 0.43 |
| ▸ | TEAD4 | Q15561 | 1/20 | 0.43 |
| ▸ | TEAD2 | Q15562 | 1/20 | 0.43 |
| ▸ | CETP | P11597 | 2/20 | 0.43 |
| ▸ | KCNQ4 | P56696 | 1/20 | 0.42 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.42 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | PDE6D | O43924 | 1/20 | 0.42 |
| ▸ | CYP4Z1 | Q86W10 | 1/20 | 0.41 |
| ▸ | CYP4F11 | Q9HBI6 | 1/20 | 0.41 |
| ▸ | CYP4F12 | Q9HCS2 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | TSPO | P30536 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2224578 | 0.86 | SMN1; SMN2 (0.54) | SMN1; SMN2POLBALDH1A1L3MBTL1 | |
| SCHEMBL2226376 | 0.81 | SMN1; SMN2 (0.51) | SMN1; SMN2POLBTDP1ALDH1A1L3MBTL1 | |
| SCHEMBL6860586 | 0.81 | SMN1; SMN2 (0.54) | SMN1; SMN2POLBTDP1ALDH1A1 | |
| SCHEMBL14007558 | 0.79 | OPRM1 (0.41) | POLBAPEX1TDP1YAP1TEAD4 | |
| SCHEMBL14129782 | 0.77 | RIPK1 (0.43) | SMN1; SMN2POLBALDH1A1 | |
| SCHEMBL5871481 | 0.75 | CYP4F2 (0.58) | TDP1CYP4F2CYP4A11CYP4Z1CYP4F11 | |
| SCHEMBL20347975 | 0.75 | REN (0.58) | SMN1; SMN2ALDH1A1 | |
| SCHEMBL1936446 | 0.75 | CYP4F2 (0.72) | TDP1CYP4F2CYP4A11ALDH1A1CYP4Z1 | |
| SCHEMBL9685398 | 0.74 | GAA (0.52) | SMN1; SMN2POLBCYP4F2CYP4A11ALDH1A1 | |
| SCHEMBL6330958 | 0.74 | CYP4Z1 (0.59) | TDP1CYP4F2CYP4A11ALDH1A1CYP4Z1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120220571-A1 | HIV INTEGRASE INHIBITORS | WAI JOHN S (US) | 2012-08-30 | — | — | US | disclosed |
| US-20120220571-A1 | HIV INTEGRASE INHIBITORS | WAI JOHN S (US) | 2012-08-30 | — | — | US | disclosed |
| US-20120220571-A1 | HIV INTEGRASE INHIBITORS | WAI JOHN S (US) | 2012-08-30 | — | — | US | disclosed |
| EP-1677599-A4 | HYDROXY PYRIDOPYRROLOPYRAZINE DIONE COMPOUNDS USEFUL AS HIV INTEGRASE INHIBITORS | MERCK & CO INC (US) | 2008-10-22 | — | — | EP | disclosed |
| US-7435735-B2 | Hydroxy pyridopyrrolopyrazine dione compounds useful as HIV integrase inhibitors | MERCK & CO., INC. (US) | 2008-10-14 | — | — | US | disclosed |
| US-7435735-B2 | Hydroxy pyridopyrrolopyrazine dione compounds useful as HIV integrase inhibitors | MERCK & CO., INC. (US) | 2008-10-14 | — | — | US | disclosed |
| US-7435735-B2 | Hydroxy pyridopyrrolopyrazine dione compounds useful as HIV integrase inhibitors | MERCK & CO., INC. (US) | 2008-10-14 | — | — | US | disclosed |
| US-20070093496-A1 | Hydroxy pyridopyrrolopyrazine dione compounds useful as hiv integrase inhibitors | MERCK SHARP & DOHME CORP. | 2007-04-26 | — | — | US | disclosed |
| US-20070093496-A1 | Hydroxy pyridopyrrolopyrazine dione compounds useful as hiv integrase inhibitors | MERCK SHARP & DOHME CORP. | 2007-04-26 | — | — | US | disclosed |
| US-20070093496-A1 | Hydroxy pyridopyrrolopyrazine dione compounds useful as hiv integrase inhibitors | MERCK SHARP & DOHME CORP. | 2007-04-26 | — | — | US | disclosed |
| EP-1677599-A1 | HYDROXY PYRIDOPYRROLOPYRAZINE DIONE COMPOUNDS USEFUL AS HIV INTEGRASE INHIBITORS | Merck & Co., Inc. (US) | 2006-07-12 | — | — | EP | disclosed |
| WO-2005041664-A1 | HYDROXY PYRIDOPYRROLOPYRAZINE DIONE COMPOUNDS USEFUL AS HIV INTEGRASE INHIBITORS | MERCK & CO., INC. (US) | 2005-05-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070093496-A1 | Hydroxy pyridopyrrolopyrazine dione compounds useful as hiv integrase inhibitors | DHPS, DPYD, TYMP | SMN1; SMN2 3773/4885POLB 20/4885APEX1 1250/4885 |
| US-20120220571-A1 | HIV INTEGRASE INHIBITORS | POLR2E, POLR2H, POLR1A | SMN1; SMN2 3600/4885POLB 8/4885APEX1 1376/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.