Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 10/20 | 0.46 |
| ▸ | HCRTR2 | O43614 | 10/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | TNF | P01375 | 1/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.34 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.34 |
| ▸ | MGLL | Q99685 | 1/20 | 0.33 |
| ▸ | PDE2A | O00408 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4695935 | 0.93 | HCRTR2 (0.47) | HCRTR1HCRTR2HPGDALDH1A1TNF | |
| SCHEMBL4694375 | 0.90 | HCRTR1 (0.40) | HCRTR1HCRTR2HPGDALDH1A1TNF | |
| SCHEMBL4692886 | 0.89 | ALDH1A1 (0.42) | HCRTR1HCRTR2HPGDALDH1A1TNF | |
| SCHEMBL4690927 | 0.89 | HCRTR1 (0.49) | HCRTR1HCRTR2ALDH1A1MGLLLMNA | |
| SCHEMBL4690680 | 0.89 | HCRTR1 (0.42) | HCRTR1HCRTR2HPGDALDH1A1TNF | |
| SCHEMBL4694334 | 0.88 | HCRTR1 (0.43) | HCRTR1HCRTR2TNF | |
| SCHEMBL4692692 | 0.86 | HCRTR1 (0.45) | HCRTR1HCRTR2ALDH1A1TNFPDE2A | |
| SCHEMBL4690403 | 0.86 | HCRTR1 (0.39) | HCRTR1HCRTR2HPGDALDH1A1TNF | |
| SCHEMBL4692944 | 0.86 | HCRTR1 (0.41) | HCRTR1HCRTR2ALDH1A1P2RX7KDM4E | |
| SCHEMBL4694969 | 0.86 | HCRTR1 (0.38) | HCRTR1HCRTR2HPGDTNFP2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1761542-B1 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | HOFFMANN LA ROCHE (CH) | 2008-01-02 | — | — | EP | claimed |
| EP-1761542-A2 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | F.HOFFMANN-LA ROCHE AG (CH) | 2007-03-14 | — | — | EP | claimed |
| WO-2005121145-A2 | OCTAHYDRO-PYRROLO[3,4-C] DERIVATIVES AND THEIR USE AS ANTIVIRAL COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-12-22 | — | — | WO | claimed |
| EP-1761542-B1 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | HOFFMANN LA ROCHE (CH) | 2008-01-02 | — | — | EP | disclosed |