SCHEMBL4695249

SCHEMBL4695249

Cc1ccc(NCCCN2CC3CN(C(=O)c4oc5ccccc5c4C)CC3C2)cc1Cl

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RECQL P46063 2/20 0.48
KMT2A Q03164 5/20 0.47
ALDH1A1 P00352 4/20 0.47
MEN1 O00255 2/20 0.47
L3MBTL1 Q9Y468 1/20 0.47
SMN1; SMN2 Q16637 4/20 0.46
HPGD P15428 1/20 0.45
TSHR P16473 1/20 0.45
HTT P42858 1/20 0.45
NPC1 O15118 3/20 0.44
KDM4E B2RXH2 2/20 0.43
RAB9A P51151 2/20 0.42
MAPT P10636 1/20 0.42
MAPK1 P28482 1/20 0.42
LMNA P02545 2/20 0.41
TP53 P04637 1/20 0.41
ADRA2A P08913 1/20 0.41
ADRA2C P18825 1/20 0.41
DRD3 P35462 1/20 0.41
HTR2B P41595 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4695245 0.86 MAPT (0.48) RECQLKMT2AALDH1A1MEN1L3MBTL1
SCHEMBL4692853 0.84 RAB9A (0.52) KMT2AALDH1A1MEN1L3MBTL1SMN1; SMN2
SCHEMBL4691640 0.83 MAPT (0.54) ALDH1A1SMN1; SMN2HTTKDM4ERAB9A
SCHEMBL4692728 0.82 CHRNB2 (0.47) KMT2AALDH1A1L3MBTL1SMN1; SMN2HTT
SCHEMBL4692889 0.82 MAPT (0.45) ALDH1A1SMN1; SMN2HPGDHTTKDM4E
SCHEMBL4693334 0.82 ALDH1A1 (0.45) KMT2AALDH1A1SMN1; SMN2HTTKDM4E
SCHEMBL4691764 0.81 CCR5 (0.42) ALDH1A1L3MBTL1SMN1; SMN2HTTKDM4E
SCHEMBL3281865 0.81 CCR5 (0.52) ALDH1A1SMN1; SMN2HTTMAPTLMNA
SCHEMBL4691905 0.81 HCRTR1 (0.47) KMT2AALDH1A1MEN1SMN1; SMN2TSHR
SCHEMBL4690668 0.81 ALDH1A1 (0.43) KMT2AALDH1A1MEN1L3MBTL1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1761542-A2 OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS F.HOFFMANN-LA ROCHE AG (CH) 2007-03-14 EP claimed
WO-2005121145-A2 OCTAHYDRO-PYRROLO[3,4-C] DERIVATIVES AND THEIR USE AS ANTIVIRAL COMPOUNDS F. HOFFMANN-LA ROCHE AG (CH) 2005-12-22 WO claimed
EP-1761542-B1 OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS HOFFMANN LA ROCHE (CH) 2008-01-02 EP disclosed