Sugi Predict

Sugi Predict / Compounds / SCHEMBL470126

SCHEMBL470126

SCHEMBL470126

Cc1ccc(OC2CC2)cc1

nearest known ligand 0.46

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
▸ ACHE P22303 2/20 0.46
▸ TEAD4 Q15561 1/20 0.44
▸ FPR2 P25090 4/20 0.44
▸ PROKR1 Q8TCW9 4/20 0.44
▸ HRH1 P35367 1/20 0.43
▸ HRH3 Q9Y5N1 2/20 0.43
▸ TDP1 Q9NUW8 2/20 0.43
▸ MAPT P10636 2/20 0.43
▸ ALDH1A1 P00352 1/20 0.43
▸ POLB P06746 1/20 0.43
▸ PARP10 Q53GL7 1/20 0.42
▸ EPHX2 P34913 1/20 0.42
▸ PTPN1 P18031 1/20 0.42
▸ EGFR P00533 1/20 0.41
▸ MAOB P27338 1/20 0.41
▸ NAAA Q02083 1/20 0.40
▸ MEN1 O00255 1/20 0.40
▸ KMT2A Q03164 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12807880 0.91 FPR2 (0.40) ACHETEAD4FPR2PROKR1HRH1
SCHEMBL20196968 0.91 FPR2 (0.40) ACHETEAD4FPR2PROKR1HRH1
SCHEMBL8171032 0.91 EGFR (0.49) ACHETEAD4FPR2PROKR1HRH3
SCHEMBL8256707 0.91 PARP10 (0.53) ACHETEAD4FPR2PROKR1HRH1
SCHEMBL8597767 0.89 TEAD4 (0.42) ACHETEAD4FPR2PROKR1HRH1
SCHEMBL17324128 0.89 TEAD4 (0.42) ACHETEAD4FPR2PROKR1HRH1
SCHEMBL8597762 0.89 FPR2 (0.40) ACHETEAD4FPR2PROKR1HRH1
SCHEMBL8597764 0.89 FPR2 (0.40) ACHETEAD4FPR2PROKR1HRH1
SCHEMBL257928 0.89 EGFR (0.48) ACHEFPR2PROKR1HRH3ALDH1A1
SCHEMBL18210781 0.89 EGFR (0.48) ACHEFPR2PROKR1HRH3ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 70 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117088796-A Method for synthesizing beta-trifluoromethylthioketone derivative by ring opening of cyclopropyl alcohol derivative 天津师范大学 2023-11-21 — — CN disclosed
CN-116730784-A Synthesis method of malonic acid derivative 华南理工大学 2023-09-12 — — CN disclosed
EP-3724188-B1 PROGRANULIN MODULATORS AND METHODS OF USING THE SAME ARKUDA THERAPEUTICS (US) 2023-06-07 — — EP disclosed
WO-2023083343-A1 POLYCYCLIC COMPOUNDS AND METHODS THEREOF HEPAITECH (BEIJING) BIOPHARMA TECHNOLOGY CO., LTD. (CN) 2023-05-19 — — WO disclosed
CN-112469768-B Polymerization condition setting method and method for producing optical material 三井化学株式会社 2023-04-28 — — CN disclosed
CN-111868099-B Method for setting polymerization conditions and method for producing optical material 三井化学株式会社 2022-12-16 — — CN disclosed
US-20210300908-A1 S1P1 AGONIST AND APPLICATION THEREOF Shijiazhuang Sagacity New Drug Development Co., Ltd. (CN) 2021-09-30 — — US disclosed
WO-2020063760-A1 NOVEL HETEROCYCLIC DERIVATIVES USEFUL AS SHP2 INHIBITORS JACOBIO PHARMACEUTICALS CO., LTD. (CN) 2020-04-02 — — WO disclosed
US-20190047968-A1 6-ACYL-1,2,4-TRIAZINE-3,5-DIONE DERIVATIVE AND HERBICIDES FMC CORP (US) 2019-02-14 — — US disclosed
EP-2297133-B1 1, 2 DISUBSTITUTED HETEROCYCLIC COMPOUNDS FORUM PHARMACEUTICALS INC (US) 2017-09-13 — — EP disclosed
WO-2010089993-A1 RING-FUSED 2-PYRIDONE DERIVATIVES AND HERBICIDES クミアイ化学工業株式会社 (JP) 2010-08-12 — — WO disclosed
WO-2009158393-A1 1, 2 DISUBSTITUTED HETEROCYCLIC COMPOUNDS ENVIVO PHARMACEUTICALS, INC. (US) 2009-12-30 — — WO disclosed
WO-2009158473-A1 5- AND 6-MEMBERED HETEROCYCLIC COMPOUNDS ENVIVO PHARMACEUTICALS, INC. (US) 2009-12-30 — — WO disclosed
WO-2009125870-A1 PYRIMIDINE, PYRIDINE AND TRIAZINE DERIVATIVES AS MAXI-K CHANNEL OPENERS. MITSUBISHI TANABE PHARMA CORPORATION (JP) 2009-10-15 — — WO disclosed
US-7579479-B2 Substituted acid derivatives useful as antidiabetic and antiobesity agents and method BRISTOL-MYERS SQUIBB COMPANY (US) 2009-08-25 — — US disclosed
US-20090203667-A1 PENTADIENAMIDE DERIVATIVES KYOWA HAKKO KIRIN CO., LTD. (JP) 2009-08-13 — — US disclosed
EP-2050734-A1 PENTADIENAMIDE DERIVATIVE Kyowa Hakko Kirin Co., Ltd. (JP) 2009-04-22 — — EP disclosed
US-20090075995-A1 MODULATORS OF GLUCOCORTICOID RECEPTOR, AP-1, AND/OR NF-kB ACTIVITY AND USE THEREOF BRISTOL-MYERS SQUIBB COMPANY 2009-03-19 — — US disclosed
US-7241780-B2 Substituted acid derivatives useful as antidiabetic and antiobesity agents and method BRISTOLS-MYERS SQUIBB COMPANY (US) 2007-07-10 — — US disclosed
US-20070015797-A1 Substituted acid derivatives useful as antidiabetic and antiobesity agents and method CHENG PETER T 2007-01-18 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090203667-A1 PENTADIENAMIDE DERIVATIVES PRMT1, REN, NGLY1 ACHE 1750/4885TEAD4 4407/4885FPR2 3918/4885
US-20090075995-A1 MODULATORS OF GLUCOCORTICOID RECEPTOR, AP-1, AND/OR NF-kB ACTIVITY AND USE THEREOF NFKB2, NFRKB, NFKB1 ACHE 4675/4885TEAD4 1571/4885FPR2 887/4885
US-20190047968-A1 6-ACYL-1,2,4-TRIAZINE-3,5-DIONE DERIVATIVE AND HERBICIDES DDT, AADAC, DAZAP1 ACHE 337/4885TEAD4 1439/4885FPR2 2833/4885
US-20210300908-A1 S1P1 AGONIST AND APPLICATION THEREOF S1PR1, S1PR2, S1PR3 ACHE 4137/4885TEAD4 3882/4885FPR2 157/4885
US-20070015797-A1 Substituted acid derivatives useful as antidiabetic and antiobesity agents and method GPR119, LIPC, ACACA ACHE 3502/4885TEAD4 3536/4885FPR2 2864/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.