Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPR3 | P17342 | 2/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | ELANE | P08246 | 6/20 | 0.43 |
| ▸ | TAS1R3 | Q7RTX0 | 6/20 | 0.43 |
| ▸ | TAS1R1 | Q7RTX1 | 6/20 | 0.43 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.41 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4701850 | 0.85 | MAPK8 (0.52) | MAPK8MEN1KMT2A | |
| SCHEMBL4701848 | 0.85 | MAPK8 (0.52) | MAPK8MEN1KMT2A | |
| SCHEMBL4701871 | 0.77 | CTSL (0.61) | — | |
| SCHEMBL13735937 | 0.74 | NPR3 (0.43) | NPR3CYP2C9CYP2C19ELANEMAPK8 | |
| SCHEMBL654903 | 0.74 | NPR3 (0.43) | NPR3CYP2C9CYP2C19ELANEMAPK8 | |
| SCHEMBL14667059 | 0.74 | NPR3 (0.43) | NPR3CYP2C9CYP2C19ELANEMAPK8 | |
| SCHEMBL14658556 | 0.74 | NPR3 (0.43) | NPR3CYP2C9CYP2C19ELANEMAPK8 | |
| SCHEMBL29761546 | 0.74 | NPR3 (0.43) | NPR3CYP2C9CYP2C19ELANEMAPK8 | |
| SCHEMBL6509026 | 0.73 | TAS1R3 (0.46) | NPR3CYP2C9CYP2C19ELANETAS1R3 | |
| SCHEMBL6508232 | 0.73 | NPR3 (0.60) | NPR3CYP2C9CYP2C19ELANETAS1R3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1372655-B1 | CATHEPSIN CYSTEINE PROTEASE INHIBITORS | MERCK FROSST CANADA LTD (CA) | 2008-10-01 | — | — | EP | disclosed |
| US-7012075-B2 | Cathepsin cysteine protease inhibitors | MERCK & CO., INC. (US) | 2006-03-14 | — | — | US | disclosed |
| EP-1372655-A4 | CATHEPSIN CYSTEINE PROTEASE INHIBITORS | MERCK FROSST CANADA INC (CA) | 2005-10-12 | — | — | EP | disclosed |
| US-20040198982-A1 | Cathepsin cysteine protease inhibitors | MERCK CANADA INC. (CA) | 2004-10-07 | — | — | US | disclosed |
| EP-1372655-A2 | CATHEPSIN CYSTEINE PROTEASE INHIBITORS | Merck Frosst Canada & Co. (CA) | 2004-01-02 | — | — | EP | disclosed |
| WO-2002069901-A2 | CATHEPSIN CYSTEINE PROTEASE INHIBITORS | MERCK FROSST CANADA & CO. (CA) | 2002-09-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040198982-A1 | Cathepsin cysteine protease inhibitors | CTSB, CTSS, CTSZ | NPR3 4602/4885CYP2C9 4018/4885CYP2C19 3731/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.