Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 5/20 | 0.38 |
| ▸ | ELANE | P08246 | 4/20 | 0.35 |
| ▸ | TP53 | P04637 | 4/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | BCHE | P06276 | 3/20 | 0.34 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.34 |
| ▸ | GRIN2A | Q12879 | 3/20 | 0.34 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.34 |
| ▸ | DHFR | P00374 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | MTOR | P42345 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13974298 | 0.89 | ACHE (0.39) | ACHEELANEBCHEGRIN1GRIN2A | |
| SCHEMBL2241078 | 0.85 | ALDH1A1 (0.35) | ELANETP53MAPTDHFRALDH1A1 | |
| SCHEMBL2513546 | 0.84 | LMNA (0.33) | TP53MAPTDHFRALDH1A1POLB | |
| SCHEMBL2243546 | 0.83 | DHFR (0.33) | HRH4DHFRALDH1A1POLBTLR7 | |
| SCHEMBL4704199 | 0.83 | KCNA5 (0.36) | TP53MAPTHRH4DHFRALDH1A1 | |
| SCHEMBL4792173 | 0.83 | TP53 (0.34) | TP53MAPTDHFRALDH1A1POLB | |
| SCHEMBL1775006 | 0.82 | MAPT (0.36) | TP53MAPTDHFRALDH1A1TLR7 | |
| SCHEMBL4794357 | 0.82 | PIK3CB (0.33) | TP53MAPTDHFRALDH1A1POLB | |
| SCHEMBL4791809 | 0.82 | POLB (0.39) | ELANETP53MAPTALDH1A1POLB | |
| SCHEMBL12097860 | 0.81 | KDM4E (0.34) | TP53MAPTALDH1A1POLBPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1831226-A4 | CHIRAL FUSED 1,2 IMIDAZO 4,5-c RING COMPOUNDS | 3M INNOVATIVE PROPERTIES CO (US) | 2008-11-05 | — | — | EP | disclosed |
| EP-1831226-A2 | CHIRAL FUSED 1,2 IMIDAZO 4,5-c RING COMPOUNDS | 3M INNOVATIVE PROPERTIES COMPANY (US) | 2007-09-12 | — | — | EP | disclosed |
| WO-2006074003-A2 | CHIRAL FUSED [1,2]IMIDAZO[4,5-c] RING COMPOUNDS | 3M INNOVATIVE PROPERTIES COMPANY (US) | 2006-07-13 | — | — | WO | disclosed |