Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 4/20 | 0.34 |
| ▸ | MAPT | P10636 | 4/20 | 0.34 |
| ▸ | GRM5 | P41594 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | DCPS | Q96C86 | 1/20 | 0.33 |
| ▸ | DHFR | P00374 | 1/20 | 0.32 |
| ▸ | TLR7 | Q9NYK1 | 6/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | GLA | P06280 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 2/20 | 0.30 |
| ▸ | NCF1 | P14598 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2513546 | 0.90 | LMNA (0.33) | TP53MAPTGRM5LMNADCPS | |
| SCHEMBL4794357 | 0.86 | PIK3CB (0.33) | TP53MAPTGRM5LMNADCPS | |
| SCHEMBL4792910 | 0.86 | TLR8 (0.37) | TP53MAPTGRM5LMNADCPS | |
| SCHEMBL1775006 | 0.86 | MAPT (0.36) | TP53MAPTGRM5LMNADHFR | |
| SCHEMBL4791809 | 0.85 | POLB (0.39) | TP53MAPTGRM5LMNADCPS | |
| SCHEMBL4702114 | 0.83 | ACHE (0.38) | TP53MAPTDHFRTLR7ALDH1A1 | |
| SCHEMBL1776124 | 0.83 | GRM5 (0.36) | TP53MAPTGRM5LMNADCPS | |
| SCHEMBL4707903 | 0.81 | TLR7 (0.37) | TP53MAPTLMNADHFRTLR7 | |
| SCHEMBL2244245 | 0.80 | DCPS (0.34) | GRM5DCPSDHFRTLR7KDM4E | |
| SCHEMBL2241078 | 0.80 | ALDH1A1 (0.35) | TP53MAPTLMNADHFRTLR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1831221-A4 | SUBSTITUTED CHIRAL FUSED 1,2 IMIDAZO 4,5-C RING COMPOUNDS | 3M INNOVATIVE PROPERTIES CO (US) | 2008-11-05 | — | — | EP | disclosed |
| EP-1831221-A2 | SUBSTITUTED CHIRAL FUSED 1,2 IMIDAZO 4,5-C RING COMPOUNDS | 3M Innovative Properties Company (US) | 2007-09-12 | — | — | EP | disclosed |
| WO-2006083440-A2 | SUBSTITUTED CHIRAL FUSED [1,2]IMIDAZO[4,5-C] RING COMPOUNDS | 3M INNOVATIVE PROPERTIES COMPANY (US) | 2006-08-10 | — | — | WO | disclosed |