Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 4/20 | 0.56 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.43 |
| ▸ | IDO1 | P14902 | 1/20 | 0.41 |
| ▸ | TDO2 | P48775 | 1/20 | 0.41 |
| ▸ | IDO2 | Q6ZQW0 | 1/20 | 0.41 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.41 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.41 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | USP9X | Q93008 | 4/20 | 0.40 |
| ▸ | DRD3 | P35462 | 2/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4702293 | 0.81 | CHRNB2 (0.50) | HTR6CHRNB2CHRNA4RXFP1 | |
| SCHEMBL9902743 | 0.80 | HTR6 (0.50) | HTR6HDAC3IDO1TDO2IDO2 | |
| SCHEMBL4702216 | 0.80 | HTR6 (0.59) | HTR6USP9XDRD3 | |
| SCHEMBL4703630 | 0.79 | ALDH1A1 (0.47) | HTR6CHRNB2CHRNA4 | |
| Hydrochloric Acid SCHEMBL4698200 | 0.79 | HTR6 (0.58) | HTR6USP9XDRD3 | |
| SCHEMBL3136898 | 0.78 | HTR6 (0.60) | HTR6SIGMAR1DRD3 | |
| SCHEMBL4690981 | 0.73 | HTR6 (0.61) | HTR6CHRNB2CHRNA4SIGMAR1DRD3 | |
| SCHEMBL4702240 | 0.73 | HTR6 (0.61) | HTR6CHRNB2CHRNA4DRD3HRH3 | |
| SCHEMBL9903085 | 0.72 | HTR6 (0.57) | HTR6CHRNB2CHRNA4 | |
| SCHEMBL9903853 | 0.70 | HTR6 (0.60) | HTR6IDO1TDO2IDO2RXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1660483-B1 | 8-(1-PIPERAZINYL)-QUINOLINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF CNS DISORDERS | GLAXO GROUP LTD (GB) | 2008-12-24 | — | — | EP | claimed |