SCHEMBL470758

SCHEMBL470758

N#C/C(=C1/c2ccccc2-c2c1c1c(c3c2/C(=C(\C#N)c2cccc4ccccc24)c2ccccc2-3)/C(=C(\C#N)c2cccc3ccccc23)c2ccccc2-1)c1cccc2ccccc12

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 3/20 0.40
ALDH1A1 P00352 3/20 0.40
HPGD P15428 3/20 0.40
HTT P42858 2/20 0.40
HSP90AA1 P07900 1/20 0.40
NR4A1 P22736 1/20 0.40
NR4A2 P43354 1/20 0.40
NR4A3 Q92570 1/20 0.40
MMP3 P08254 1/20 0.37
HDAC8 Q9BY41 1/20 0.37
CYP1A2 P05177 1/20 0.36
CYP2C9 P11712 1/20 0.36
CYP2C19 P33261 1/20 0.36
PTPN1 P18031 1/20 0.36
CDC25B P30305 1/20 0.36
PLK1 P53350 1/20 0.36
L3MBTL1 Q9Y468 2/20 0.35
PTK2B Q14289 1/20 0.35
MCL1 Q07820 1/20 0.34
CA1 P00915 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26303258 0.79 ALDH1A1 (0.43) MAPTALDH1A1HPGDHTTHSP90AA1
SCHEMBL470757 0.73 CHRNB2 (0.38) MAPTALDH1A1HTTCYP1A2CYP2C9
SCHEMBL470760 0.72 CES2 (0.41) MAPTALDH1A1HPGDHDAC8CYP1A2
SCHEMBL470752 0.68 MAPT (0.37) MAPTALDH1A1HTTMEN1KMT2A
SCHEMBL470756 0.68 MEN1 (0.35) MAPTALDH1A1HPGDHTTCYP1A2
SCHEMBL470762 0.68 CES2 (0.37) MAPTALDH1A1HTTMEN1KMT2A
SCHEMBL8086289 0.67 PTK2B (0.50) MAPTALDH1A1HPGDHTTHSP90AA1
SCHEMBL9442057 0.67 NR4A1 (0.59) MAPTALDH1A1HPGDHTTHSP90AA1
SCHEMBL10023031 0.67 MAPT (0.48) MAPTALDH1A1HPGDHTTL3MBTL1
SCHEMBL13966683 0.65 NR4A1 (0.46) MAPTALDH1A1HPGDHTTHSP90AA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20140144509-A1 Compounds for Organic Photovoltaic Devices NOVALED AG (DE) 2014-05-29 US disclosed
WO-2012031735-A1 COMPOUNDS FOR ORGANIC PHOTOVOLTAIC DEVICES NOVALED AG (DE) 2012-03-15 WO disclosed