Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCI | P41743 | 2/20 | 0.43 |
| ▸ | ATR | Q13535 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | RET | P07949 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | GBA1 | P04062 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4710354 | 0.87 | KMT2A (0.46) | PRKCIATRALDH1A1NPC1TP53 | |
| SCHEMBL5291491 | 0.82 | MAPK1 (0.51) | PRKCIATRALDH1A1NPC1RAB9A | |
| SCHEMBL4884927 | 0.82 | KDM4E (0.54) | PRKCIATRALDH1A1NPC1TP53 | |
| SCHEMBL6053589 | 0.74 | MAPT (0.45) | PRKCIATRALDH1A1NPC1RAB9A | |
| SCHEMBL5200379 | 0.73 | KMT2A (0.53) | ATRKMT2A | |
| SCHEMBL4708765 | 0.68 | L3MBTL1 (0.51) | ALDH1A1NPC1TP53RAB9ASMN1; SMN2 | |
| SCHEMBL5233290 | 0.68 | RAB9A (0.51) | ALDH1A1NPC1TP53PKMRAB9A | |
| SCHEMBL4312329 | 0.68 | NPC1 (0.57) | NPC1TP53PKMRAB9ASMN1; SMN2 | |
| SCHEMBL3845313 | 0.68 | NPC1 (0.57) | NPC1TP53PKMRAB9ASMN1; SMN2 | |
| SCHEMBL4710352 | 0.68 | KDM4E (0.54) | PRKCIATRALDH1A1KDM4EALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1824844-B1 | PYRAZINE DICARBOXAMIDES AND THE USE THEREOF | BAYER HEALTHCARE AG (DE) | 2008-11-05 | — | — | EP | disclosed |