Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 4/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | OXTR | P30559 | 1/20 | 0.35 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.34 |
| ▸ | HCRTR1 | O43613 | 4/20 | 0.34 |
| ▸ | HCRTR2 | O43614 | 4/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4713873 | 0.78 | HRH3 (0.38) | OPRM1ALDH1A1 | |
| SCHEMBL4715539 | 0.75 | ALDH1A1 (0.41) | ALDH1A1NOTUMHPGDLMNA | |
| SCHEMBL4716542 | 0.74 | LMNA (0.41) | OPRM1ALDH1A1LMNA | |
| SCHEMBL4713689 | 0.74 | SMN1; SMN2 (0.38) | OPRM1ALDH1A1HPGD | |
| SCHEMBL4714369 | 0.73 | OPRM1 (0.42) | OPRM1KDM4EALDH1A1NOTUMHPGD | |
| SCHEMBL4714471 | 0.73 | OXTR (0.38) | ALDH1A1OXTR | |
| SCHEMBL4713625 | 0.72 | CYP2D6 (0.38) | KDM4EALDH1A1OXTRHPGD | |
| SCHEMBL4714260 | 0.71 | MEN1 (0.43) | KDM4EALDH1A1LMNA | |
| SCHEMBL4716576 | 0.70 | ALDH1A1 (0.40) | OPRM1KDM4EALDH1A1HPGDLMNA | |
| SCHEMBL1575172 | 0.70 | KDM4E (0.58) | KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1933830-A1 | ANTAGONISTS OF SNS SODIUM CHANNELS | Vernalis (R&D) Limited (GB) | 2008-06-25 | — | — | EP | disclosed |
| WO-2007007057-A1 | ANTAGONISTS OF SNS SODIUM CHANNELS | VERNALIS (R & D) LIMITED (GB) | 2007-01-18 | — | — | WO | disclosed |