Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | FAAH | O00519 | 7/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4828824 | 0.88 | LMNA (0.56) | LMNASMN1; SMN2KMT2AMEN1TSHR | |
| SCHEMBL2234600 | 0.84 | HRH3 (0.53) | LMNASMN1; SMN2KMT2AMEN1TSHR | |
| SCHEMBL29977618 | 0.84 | PRMT6 (0.64) | LMNASMN1; SMN2KMT2AMEN1TSHR | |
| SCHEMBL2925701 | 0.82 | ALDH1A1 (0.59) | LMNASMN1; SMN2KMT2AMEN1TSHR | |
| SCHEMBL2850013 | 0.81 | ALDH1A1 (0.70) | LMNASMN1; SMN2KMT2AMEN1TSHR | |
| SCHEMBL4838001 | 0.81 | CYP2D6 (0.73) | LMNASMN1; SMN2KMT2AMEN1TSHR | |
| SCHEMBL3093924 | 0.81 | FAAH (0.70) | SMN1; SMN2KMT2AMEN1TSHRFAAH | |
| SCHEMBL2930424 | 0.81 | SIGMAR1 (0.73) | LMNASMN1; SMN2KMT2AMEN1TSHR | |
| SCHEMBL6865542 | 0.81 | ALDH1A1 (0.72) | LMNASMN1; SMN2KMT2AMEN1TSHR | |
| SCHEMBL3948130 | 0.81 | LMNA (0.55) | LMNASMN1; SMN2KMT2AMEN1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1959963-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS AND METHODS | Cytokinetics, Inc. (US) | 2008-08-27 | — | — | EP | disclosed |
| EP-1959947-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS AND METHODS | Cytokinetics, Inc. (US) | 2008-08-27 | — | — | EP | disclosed |
| WO-2007089336-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS AND METHODS | CYTOKINETICS, INC. (US) | 2007-08-09 | — | — | WO | disclosed |
| WO-2007075377-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS AND METHODS | CYTOKINETICS, INC. (US) | 2007-07-05 | — | — | WO | disclosed |