Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | ELANE | P08246 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | GMNN | O75496 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | CTSG | P08311 | 1/20 | 0.42 |
| ▸ | CTSA | P10619 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21477512 | 0.98 | PARP1 (0.44) | PARP1HSD17B10TSHRMAPK1HTT | |
| SCHEMBL23537551 | 0.79 | ALDH1A1 (0.47) | HSD17B10MAPK1ALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL30023090 | 0.79 | ALDH1A1 (0.47) | HSD17B10MAPK1ALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL23537530 | 0.76 | ALDH1A1 (0.47) | HSD17B10HTTALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL313890 | 0.75 | CYP3A4 (0.56) | HSD17B10TSHRALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL29576889 | 0.73 | MAOA (0.55) | HSD17B10MAPK1ALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL3628571 | 0.73 | MAOA (0.55) | HSD17B10MAPK1ALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL24891350 | 0.72 | ELANE (0.61) | HSD17B10MAPK1ALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL15416284 | 0.72 | PSMD14 (0.40) | PARP1HSD17B10HTTALDH1A1ELANE | |
| Bicarbonate SCHEMBL11464438 | 0.72 | CYP1A2 (0.53) | TSHRALDH1A1CYP1A2CYP2C19SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1957475-A1 | CHROMENONES AND THEIR USE AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | Merz Pharma GmbH & Co.KGaA (DE) | 2008-08-20 | — | — | EP | disclosed |
| WO-2007045876-A1 | CHROMENONES AND THEIR USE AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2007-04-26 | — | — | WO | disclosed |
| EP-0218195-A2 | Bis(dibenzo[b,d]pyranyloxy)propanes | PENNWALT CORPORATION (US) | 1987-04-15 | — | — | EP | disclosed |