Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM4 | Q14833 | 1/20 | 0.48 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.48 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.48 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.48 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.48 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.42 |
| ▸ | LTA4H | P09960 | 1/20 | 0.42 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.41 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.41 |
| ▸ | MBOAT4 | Q96T53 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26317133 | 0.82 | CYP11B1 (0.43) | GRM4KCNQ3KCNQ2KCNE1KCNQ1 | |
| SCHEMBL28892361 | 0.81 | OXTR (0.49) | GRM4KCNQ3KCNQ2KCNE1KCNQ1 | |
| SCHEMBL21384231 | 0.79 | LTA4H (0.49) | SRD5A2LTA4HCYP11B1CYP11B2MBOAT4 | |
| SCHEMBL29364836 | 0.78 | KCNQ3 (0.53) | GRM4KCNQ3KCNQ2KCNE1KCNQ1 | |
| SCHEMBL41029 | 0.78 | KCNQ3 (0.53) | GRM4KCNQ3KCNQ2KCNE1KCNQ1 | |
| SCHEMBL2096666 | 0.78 | SRD5A2 (0.59) | SRD5A2ALDH1A1LTA4HKDM4E | |
| SCHEMBL7784836 | 0.77 | L3MBTL1 (0.55) | ALDH1A1CYP11B1CYP11B2KDM4EGAA | |
| Methylene Chloride SCHEMBL28144830 | 0.77 | GRM4 (0.49) | GRM4KCNQ3KCNQ2KCNE1KCNQ1 | |
| SCHEMBL11926053 | 0.77 | P2RX3 (0.50) | SRD5A2ALDH1A1LTA4HKDM4E | |
| SCHEMBL1744141 | 0.76 | KIF11 (0.52) | GRM4KCNQ3KCNQ2KCNE1KCNQ1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2832733-B1 | 4-ALKANOYLAMINO-3-PYRAZOLONE DERIVATIVE | DAIICHI SANKYO CO LTD (JP) | 2018-08-29 | — | — | EP | disclosed |
| US-9212170-B2 | 4-alkanoylamino-3-pyrazolone derivative | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2015-12-15 | — | — | US | disclosed |
| EP-2832733-A1 | 4-ALKANOYLAMINO-3-PYRAZOLONE DERIVATIVE | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2015-02-04 | — | — | EP | disclosed |
| CN-104321318-A | 4-alkanoylamino-3-pyrazolone derivative | DAIICHI SANKYO CO LTD | 2015-01-28 | — | — | CN | disclosed |
| US-20150011552-A1 | 4-ALKANOYLAMINO-3-PYRAZOLONE DERIVATIVE | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2015-01-08 | — | — | US | disclosed |
| EP-1957073-A2 | MEDICINAL DRUG | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2008-08-20 | — | — | EP | disclosed |
| WO-2007066784-A2 | DIARYLETHER DERIVATIVES AS ANTITUMOR AGENTS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2007-06-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150011552-A1 | 4-ALKANOYLAMINO-3-PYRAZOLONE DERIVATIVE | EPOR, EGLN2, EGLN3 | GRM4 4552/4885KCNQ3 889/4885KCNQ2 759/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.