Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 2/20 | 0.58 |
| ▸ | NPC1 | O15118 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.54 |
| ▸ | IGF1R | P08069 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | GABRP | O00591 | 3/20 | 0.51 |
| ▸ | GABRD | O14764 | 3/20 | 0.51 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.51 |
| ▸ | GABRB1 | P18505 | 3/20 | 0.51 |
| ▸ | GABRG2 | P18507 | 3/20 | 0.51 |
| ▸ | GABRB3 | P28472 | 3/20 | 0.51 |
| ▸ | GABRA5 | P31644 | 3/20 | 0.51 |
| ▸ | GABRA3 | P34903 | 3/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26090898 | 0.79 | RAB9A (0.76) | RAB9ANPC1ALDH1A1KMT2AIGF1R | |
| SCHEMBL4715545 | 0.76 | ALDH1A1 (0.54) | RAB9ANPC1ALDH1A1KMT2ALMNA | |
| SCHEMBL4760802 | 0.74 | RAB9A (1.00) | RAB9ANPC1ALDH1A1KMT2AIGF1R | |
| SCHEMBL30712063 | 0.72 | NPC1 (0.71) | RAB9ANPC1KMT2AIGF1RPOLB | |
| SCHEMBL1558423 | 0.71 | ALDH1A1 (1.00) | RAB9AALDH1A1KMT2ALMNAKDM4E | |
| SCHEMBL20267059 | 0.70 | HPGD (0.61) | ALDH1A1KMT2ALMNAKDM4EMEN1 | |
| SCHEMBL31060147 | 0.70 | POLB (0.73) | RAB9ANPC1KMT2AIGF1RPOLB | |
| SCHEMBL3722135 | 0.70 | ALDH1A1 (0.61) | ALDH1A1KMT2ALMNAKDM4EMEN1 | |
| SCHEMBL30712070 | 0.69 | GABRP (0.72) | RAB9ANPC1KMT2AIGF1RPOLB | |
| SCHEMBL393338 | 0.69 | CFTR (0.57) | ALDH1A1KMT2APOLBMEN1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1933831-A2 | MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | Vertex Pharmaceuticals, Inc. (US) | 2008-06-25 | — | — | EP | claimed |
| WO-2007044560-A2 | MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-04-19 | — | — | WO | claimed |