Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | MAPT | P10636 | 5/20 | 0.47 |
| ▸ | CES2 | O00748 | 3/20 | 0.46 |
| ▸ | CES1 | P23141 | 3/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | BCHE | P06276 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.39 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30089319 | 0.82 | MEN1 (0.48) | ALDH1A1MAPTCES2CES1ALOX15 | |
| SCHEMBL23881561 | 0.82 | MEN1 (0.48) | ALDH1A1MAPTCES2CES1ALOX15 | |
| SCHEMBL5807527 | 0.81 | MAPT (0.63) | ALDH1A1MAPTGAAHPGDMEN1 | |
| SCHEMBL4710844 | 0.80 | MAPT (0.45) | ALDH1A1MAPTCES2CES1ALOX15 | |
| Water SCHEMBL27623262 | 0.80 | CES2 (0.62) | ALDH1A1MAPTCES2CES1ALOX15 | |
| SCHEMBL30089335 | 0.79 | MAPT (0.55) | ALDH1A1MAPTCES2CES1ALOX15 | |
| SCHEMBL23881551 | 0.79 | MAPT (0.55) | ALDH1A1MAPTCES2CES1ALOX15 | |
| SCHEMBL5282720 | 0.78 | MAPT (0.59) | ALDH1A1MAPTCES2CES1ALOX15 | |
| SCHEMBL29664874 | 0.78 | MAPT (0.59) | ALDH1A1MAPTCES2CES1ALOX15 | |
| SCHEMBL1512043 | 0.78 | MMP2 (0.47) | ALDH1A1MAPTGAAHPGDMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8268857-B2 | Compositions and methods for inhibiting TGF-β | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2012-09-18 | — | — | US | disclosed |
| EP-1603908-B1 | QUINAZOLINE DERIVATIVES AS TGF-BETA INHIBITORS | MILLENNIUM PHARM INC (US) | 2008-06-11 | — | — | EP | disclosed |
| US-20070142408-A1 | Compositions and methods for inhibiting TGF-Beta | MILLENNIUM PHARMACEUTICALS, INC. | 2007-06-21 | — | — | US | disclosed |
| US-7189733-B2 | Compositions and methods for inhibiting TGF-β | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2007-03-13 | — | — | US | disclosed |
| EP-1603908-A1 | QUINAZOLINE DERIVATIVES AS TGF-BETA INHIBITORS | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2005-12-14 | — | — | EP | disclosed |
| US-20040204431-A1 | Compositions and methods for inhibiting TGF-beta | MILLENNIUM PHARMACEUTICALS, INC. | 2004-10-14 | — | — | US | disclosed |
| WO-2004081009-A1 | QUINAZOLINE DERIVATIVES AS TGF-BETA INHIBITORS | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2004-09-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040204431-A1 | Compositions and methods for inhibiting TGF-beta | TGFB1, TGFBR2, TGFB2 | ALDH1A1 2279/4885MAPT 3416/4885CES2 2426/4885 |
| US-20070142408-A1 | Compositions and methods for inhibiting TGF-Beta | TGFB1, TGFB2, TGFBR1 | ALDH1A1 1594/4885MAPT 2547/4885CES2 3454/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.