Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | CTSL | P07711 | 2/20 | 0.44 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CES2 | O00748 | 1/20 | 0.40 |
| ▸ | CES1 | P23141 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | IKBKB | O14920 | 1/20 | 0.36 |
| ▸ | GSTA1 | P08263 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.35 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.35 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4716637 | 0.80 | ALDH1A1 (0.47) | MAPTALDH1A1CES2CES1ALOX15 | |
| SCHEMBL1623334 | 0.80 | MAPT (0.46) | MAPTALOX15KMT2AHTTHSD17B10 | |
| SCHEMBL638047 | 0.77 | MAPT (0.63) | MAPTALDH1A1CTSLDGAT1POLB | |
| SCHEMBL30375142 | 0.77 | MAPT (0.63) | MAPTALDH1A1CTSLDGAT1POLB | |
| SCHEMBL2703001 | 0.76 | MAPT (0.56) | MAPTALDH1A1CTSLDGAT1POLB | |
| Water SCHEMBL27623262 | 0.74 | CES2 (0.62) | MAPTALDH1A1DGAT1CES2CES1 | |
| SCHEMBL80721 | 0.72 | CES2 (0.65) | MAPTALDH1A1DGAT1CES2CES1 | |
| SCHEMBL29482931 | 0.72 | CES2 (0.65) | MAPTALDH1A1DGAT1CES2CES1 | |
| SCHEMBL15263472 | 0.72 | CTSL (0.63) | MAPTALDH1A1CTSLPOLBCES2 | |
| SCHEMBL23723698 | 0.71 | DGAT1 (0.48) | MAPTDGAT1KMT2AIKBKBKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8268857-B2 | Compositions and methods for inhibiting TGF-β | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2012-09-18 | — | — | US | disclosed |
| EP-1603908-B1 | QUINAZOLINE DERIVATIVES AS TGF-BETA INHIBITORS | MILLENNIUM PHARM INC (US) | 2008-06-11 | — | — | EP | disclosed |
| US-20070142408-A1 | Compositions and methods for inhibiting TGF-Beta | MILLENNIUM PHARMACEUTICALS, INC. | 2007-06-21 | — | — | US | disclosed |
| US-7189733-B2 | Compositions and methods for inhibiting TGF-β | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2007-03-13 | — | — | US | disclosed |
| EP-1603908-A1 | QUINAZOLINE DERIVATIVES AS TGF-BETA INHIBITORS | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2005-12-14 | — | — | EP | disclosed |
| US-20040204431-A1 | Compositions and methods for inhibiting TGF-beta | MILLENNIUM PHARMACEUTICALS, INC. | 2004-10-14 | — | — | US | disclosed |
| WO-2004081009-A1 | QUINAZOLINE DERIVATIVES AS TGF-BETA INHIBITORS | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2004-09-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040204431-A1 | Compositions and methods for inhibiting TGF-beta | TGFB1, TGFBR2, TGFB2 | MAPT 3416/4885ALDH1A1 2279/4885CTSL 1665/4885 |
| US-20070142408-A1 | Compositions and methods for inhibiting TGF-Beta | TGFB1, TGFB2, TGFBR1 | MAPT 2547/4885ALDH1A1 1594/4885CTSL 2112/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.