Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.47 |
| ▸ | MEN1 | O00255 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.45 |
| ▸ | RELA | Q04206 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.45 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4722528 | 0.88 | CENPE (0.53) | MAPTMEN1KMT2APOLBTDP1 | |
| SCHEMBL4721352 | 0.85 | L3MBTL1 (0.42) | MAPTMEN1KMT2ATDP1KDM4E | |
| SCHEMBL4719311 | 0.78 | PPARG (0.42) | MAPTMEN1KMT2AKDM4ENPC1 | |
| SCHEMBL4721152 | 0.77 | CENPE (0.52) | MAPTMEN1KMT2ASMN1; SMN2LMNA | |
| SCHEMBL4718072 | 0.75 | CENPE (0.46) | MEN1KMT2ATDP1KDM4EALDH1A1 | |
| SCHEMBL2104733 | 0.74 | CENPE (0.56) | MAPTMEN1KMT2APOLBTDP1 | |
| SCHEMBL4773750 | 0.74 | MAPT (0.49) | MAPTMEN1KMT2APOLBTDP1 | |
| SCHEMBL4720776 | 0.72 | CENPE (0.44) | MAPTMEN1KMT2APOLBKDM4E | |
| SCHEMBL4720908 | 0.71 | MEN1 (0.47) | MEN1KMT2AKDM4EHPGDRAB9A | |
| SCHEMBL4521076 | 0.69 | CENPE (0.47) | MAPTMEN1KMT2AKDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1951719-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | Cytokinetics, Inc. (US) | 2008-08-06 | — | — | EP | disclosed |
| WO-2007056469-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | CYTOKINETICS, INC. (US) | 2007-05-18 | — | — | WO | disclosed |