Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4718072 | 0.88 | CENPE (0.46) | L3MBTL1ALOX5PTGS1PTGS2ALDH1A1 | |
| SCHEMBL4720087 | 0.85 | MAPT (0.47) | MAPTTP53ALDH1A1HPGDMEN1 | |
| SCHEMBL4720150 | 0.80 | PTGES (0.46) | L3MBTL1HDAC1ALOX5MAPTALDH1A1 | |
| SCHEMBL4719311 | 0.79 | PPARG (0.42) | ATMMAPTTP53THRBALDH1A1 | |
| SCHEMBL4721237 | 0.77 | SPHK2 (0.44) | ALOX5PTGS1PTGS2ALDH1A1KMT2A | |
| SCHEMBL4720908 | 0.77 | MEN1 (0.47) | HDAC1HDAC2HPGDMEN1KMT2A | |
| SCHEMBL4721152 | 0.75 | CENPE (0.52) | MAPTTP53MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL4884258 | 0.74 | CSNK2A1 (0.55) | ATMTP53ALDH1A1MEN1KMT2A | |
| SCHEMBL2103273 | 0.74 | CENPE (0.50) | L3MBTL1ALOX5PTGS1PTGS2MAPT | |
| SCHEMBL4718727 | 0.74 | CENPE (0.42) | L3MBTL1HDAC3HDAC1HDAC2NCOR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1951719-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | Cytokinetics, Inc. (US) | 2008-08-06 | — | — | EP | disclosed |
| WO-2007056469-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | CYTOKINETICS, INC. (US) | 2007-05-18 | — | — | WO | disclosed |