Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLOD2 | O00469 | 1/20 | 0.58 |
| ▸ | NPC1 | O15118 | 3/20 | 0.55 |
| ▸ | RAB9A | P51151 | 2/20 | 0.55 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.49 |
| ▸ | HTR7 | P34969 | 1/20 | 0.48 |
| ▸ | CES2 | O00748 | 1/20 | 0.48 |
| ▸ | CES1 | P23141 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3846985 | 0.85 | PLOD2 (0.60) | PLOD2NPC1RAB9APTPN1MAPT | |
| SCHEMBL2491432 | 0.84 | PLOD2 (0.69) | PLOD2NPC1RAB9APTPN1MAPT | |
| Hydrochloric Acid SCHEMBL3856158 | 0.83 | PLOD2 (0.58) | PLOD2NPC1RAB9APTPN1MAPT | |
| SCHEMBL30305722 | 0.82 | PLOD2 (0.56) | PLOD2NPC1RAB9APTPN1MAPT | |
| SCHEMBL8599336 | 0.78 | CYP3A4 (0.70) | PLOD2NPC1RAB9APTPN1MAPT | |
| SCHEMBL11175600 | 0.78 | PLOD2 (0.62) | PLOD2NPC1RAB9APTPN1MAPT | |
| SCHEMBL30114978 | 0.78 | PLOD2 (0.62) | PLOD2NPC1RAB9APTPN1MAPT | |
| SCHEMBL904555 | 0.78 | PLOD2 (0.62) | PLOD2NPC1RAB9APTPN1MAPT | |
| SCHEMBL10731900 | 0.77 | MEN1 (0.74) | PLOD2NPC1RAB9APTPN1MAPT | |
| Fluoride SCHEMBL11175607 | 0.77 | PLOD2 (0.60) | PLOD2NPC1RAB9APTPN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101437799-B | P38map kinase inhibitors | CHROMA THERAPEUTICS LTD | 2012-12-26 | — | — | CN | disclosed |
| CN-101437799-A | P38MAP kinase inhibitors | CHROMA THERAPEUTICS LTD (GB) | 2009-05-20 | — | — | CN | disclosed |
| EP-1871770-A1 | ORTHO-TERPHENYL INHIBITORS OF P38 KINASE AND METHODS OF TREATING INFLAMMATORY DISORDERS | Kalypsys, Inc. (US) | 2008-01-02 | — | — | EP | disclosed |
| US-20060252807-A1 | Novel ortho-terphenyl inhibitors of p38 kinase and methods of treating inflammatory disorders | KALYPSYS, INC. | 2006-11-09 | — | — | US | disclosed |
| WO-2006116355-A1 | ORTHO-TERPHENYL INHIBITORS OF P38 KINASE AND METHODS OF TREATING INFLAMMATORY DISORDERS | KALYPSYS, INC. (US) | 2006-11-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060252807-A1 | Novel ortho-terphenyl inhibitors of p38 kinase and methods of treating inflammatory disorders | MAPK1, MAP3K1, MAPK4 | PLOD2 3432/4885NPC1 1832/4885RAB9A 883/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.