Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CENPE | Q02224 | 2/20 | 0.47 |
| ▸ | KIFC1 | Q9BW19 | 1/20 | 0.42 |
| ▸ | TAS1R3 | Q7RTX0 | 5/20 | 0.40 |
| ▸ | TAS1R1 | Q7RTX1 | 5/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.40 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.40 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.40 |
| ▸ | RORC | P51449 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | WDR5 | P61964 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4721149 | 0.88 | CENPE (0.55) | CENPEKIFC1TAS1R3TAS1R1ROCK2 | |
| SCHEMBL4720085 | 0.85 | CENPE (0.54) | CENPEROCK2RORCPOLBMEN1 | |
| SCHEMBL4718071 | 0.85 | CENPE (0.49) | CENPEPOLBMEN1KMT2AALDH1A1 | |
| SCHEMBL2104606 | 0.81 | CENPE (0.48) | CENPEKIFC1TAS1R3TAS1R1ROCK2 | |
| SCHEMBL4720907 | 0.81 | TRPM8 (0.50) | CENPESMPD1MEN1KMT2AALDH1A1 | |
| SCHEMBL4720148 | 0.80 | PTGES (0.52) | CENPESMPD1POLBMEN1KMT2A | |
| SCHEMBL2617282 | 0.78 | GAA (0.49) | CENPECSNK2A1POLBMEN1KMT2A | |
| SCHEMBL4717868 | 0.77 | HDAC3 (0.46) | CENPE | |
| SCHEMBL13162181 | 0.76 | CENPE (0.62) | CENPEKIFC1TAS1R3TAS1R1ROCK2 | |
| SCHEMBL2617156 | 0.76 | CENPE (0.79) | CENPEKIFC1TAS1R3TAS1R1CSNK2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1951719-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | Cytokinetics, Inc. (US) | 2008-08-06 | — | — | EP | disclosed |
| WO-2007056469-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | CYTOKINETICS, INC. (US) | 2007-05-18 | — | — | WO | disclosed |