Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES | O14684 | 1/20 | 0.52 |
| ▸ | CENPE | Q02224 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.43 |
| ▸ | CTSK | P43235 | 1/20 | 0.43 |
| ▸ | GPR132 | Q9UNW8 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.42 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.42 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.42 |
| ▸ | MRGPRX4 | Q96LA9 | 3/20 | 0.42 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4718071 | 0.92 | CENPE (0.49) | PTGESCENPEHDAC1KMT2ACTSK | |
| SCHEMBL4720907 | 0.88 | TRPM8 (0.50) | CENPEHDAC1HDAC8HDAC6KMT2A | |
| SCHEMBL2103625 | 0.84 | PTGES (0.48) | PTGESCENPEHDAC1HDAC8HDAC6 | |
| SCHEMBL4721149 | 0.84 | CENPE (0.55) | CENPEKMT2ASMPD1MEN1 | |
| SCHEMBL4720085 | 0.82 | CENPE (0.54) | PTGESCENPEHDAC1HDAC8HDAC6 | |
| SCHEMBL4720774 | 0.80 | CENPE (0.47) | CENPEKMT2ASMPD1MEN1POLB | |
| SCHEMBL4721235 | 0.79 | CENPE (0.44) | PTGESCENPEHDAC1KMT2AMEN1 | |
| SCHEMBL4720150 | 0.79 | PTGES (0.46) | PTGESCENPEHDAC1HDAC8HDAC6 | |
| SCHEMBL2617475 | 0.78 | HDAC3 (0.51) | CENPEHDAC1KMT2AMEN1POLB | |
| SCHEMBL4717868 | 0.77 | HDAC3 (0.46) | CENPEHDAC1HDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1951719-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | Cytokinetics, Inc. (US) | 2008-08-06 | — | — | EP | disclosed |
| WO-2007056469-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | CYTOKINETICS, INC. (US) | 2007-05-18 | — | — | WO | disclosed |