Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES | O14684 | 2/20 | 0.46 |
| ▸ | CENPE | Q02224 | 1/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | LTC4S | Q16873 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | EPOR | P19235 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.39 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4718072 | 0.92 | CENPE (0.46) | PTGESCENPEALOX5KMT2AALDH1A1 | |
| SCHEMBL4720908 | 0.88 | MEN1 (0.47) | CENPEKMT2ASMN1; SMN2NPC1HPGD | |
| SCHEMBL2103625 | 0.86 | PTGES (0.48) | PTGESCENPEALOX5LTC4SKMT2A | |
| SCHEMBL4721152 | 0.84 | CENPE (0.52) | CENPEKMT2ASMN1; SMN2MAPTP2RX3 | |
| SCHEMBL4721237 | 0.82 | SPHK2 (0.44) | CENPEALOX5KMT2AALDH1A1TSHR | |
| SCHEMBL4722528 | 0.81 | CENPE (0.53) | CENPEKMT2ASMN1; SMN2NPC1ALDH1A1 | |
| SCHEMBL4721352 | 0.80 | L3MBTL1 (0.42) | ALOX5KMT2ASMN1; SMN2NPC1ALDH1A1 | |
| SCHEMBL4720776 | 0.80 | CENPE (0.44) | CENPEKMT2AALDH1A1MAPTHPGD | |
| SCHEMBL4720148 | 0.79 | PTGES (0.52) | PTGESCENPEKMT2AHDAC1HDAC8 | |
| SCHEMBL2103273 | 0.78 | CENPE (0.50) | PTGESCENPEALOX5KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1951719-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | Cytokinetics, Inc. (US) | 2008-08-06 | — | — | EP | disclosed |
| WO-2007056469-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | CYTOKINETICS, INC. (US) | 2007-05-18 | — | — | WO | disclosed |