Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 8/20 | 0.46 |
| ▸ | PDE3A | Q14432 | 8/20 | 0.46 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | RORC | P51449 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | CFTR | P13569 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4723904 | 0.87 | PDE3B (0.40) | PDE3BPDE3APPARGRORCKMT2A | |
| SCHEMBL4724319 | 0.80 | PDE3B (0.36) | PDE3BPDE3AALDH1A1PPARGRORC | |
| SCHEMBL4722184 | 0.79 | PDE3B (0.33) | PDE3BPDE3APPARGRORCKMT2A | |
| SCHEMBL14102084 | 0.79 | PDE3B (0.34) | PDE3BPDE3APPARGRORCKMT2A | |
| SCHEMBL4722680 | 0.78 | WDR5 (0.35) | PDE3BPDE3APPARGRORCKMT2A | |
| Hydrochloric Acid SCHEMBL4765559 | 0.78 | PDE3B (0.33) | PDE3BPDE3AALDH1A1PPARGRORC | |
| SCHEMBL18796708 | 0.73 | PDE3B (0.80) | PDE3BPDE3AALDH1A1KMT2AMEN1 | |
| SCHEMBL29200214 | 0.73 | ALDH1A1 (0.55) | PDE3BPDE3APDK2ALDH1A1KMT2A | |
| SCHEMBL4718971 | 0.73 | CHRM5 (0.33) | PDE3BPDE3APPARGRORCKMT2A | |
| SCHEMBL18152850 | 0.72 | MAPK1 (0.50) | PDE3BPDE3AALDH1A1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1953147-A1 | HETEROCYCLIC COMPOUND AND MEDICINAL APPLICATION THEREOF | Japan Tobacco, Inc. (JP) | 2008-08-06 | — | — | EP | disclosed |
| EP-1953147-A1 | HETEROCYCLIC COMPOUND AND MEDICINAL APPLICATION THEREOF | Japan Tobacco, Inc. (JP) | 2008-08-06 | — | — | EP | disclosed |