Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPHK2 | Q9NRA0 | 2/20 | 0.44 |
| ▸ | F7 | P08709 | 1/20 | 0.40 |
| ▸ | CENPE | Q02224 | 1/20 | 0.40 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | KLK1 | P06870 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4718072 | 0.89 | CENPE (0.46) | CENPETDP1KLK1KMT2ATSHR | |
| SCHEMBL2103976 | 0.87 | SPHK2 (0.46) | SPHK2CENPEPARP10KMT2AKDM4E | |
| SCHEMBL4718727 | 0.82 | CENPE (0.42) | SPHK2CENPETDP1KLK1KMT2A | |
| SCHEMBL4720150 | 0.82 | PTGES (0.46) | CENPEKMT2ATSHRALOX5ALDH1A1 | |
| SCHEMBL4719465 | 0.80 | GUSB (0.48) | CENPEKMT2ATSHRALOX5PTGS1 | |
| SCHEMBL2103273 | 0.79 | CENPE (0.50) | CENPEKMT2AALOX5PTGS1PTGS2 | |
| SCHEMBL4720908 | 0.79 | MEN1 (0.47) | CENPEKMT2AKDM4ECYP1A2CYP2C9 | |
| SCHEMBL4521076 | 0.79 | CENPE (0.47) | CENPEKMT2AKDM4ECYP1A2CYP2C9 | |
| SCHEMBL2106356 | 0.78 | SPHK2 (0.44) | SPHK2CENPETDP1KMT2AKDM4E | |
| SCHEMBL4721152 | 0.78 | CENPE (0.52) | CENPEKMT2ACYP1A2CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1951719-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | Cytokinetics, Inc. (US) | 2008-08-06 | — | — | EP | claimed |
| WO-2007056469-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | CYTOKINETICS, INC. (US) | 2007-05-18 | — | — | WO | claimed |
| EP-1951719-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | Cytokinetics, Inc. (US) | 2008-08-06 | — | — | EP | disclosed |
| WO-2007056469-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | CYTOKINETICS, INC. (US) | 2007-05-18 | — | — | WO | disclosed |