Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 5/20 | 0.43 |
| ▸ | OGA | O60502 | 1/20 | 0.42 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.40 |
| ▸ | PTPN11 | Q06124 | 2/20 | 0.38 |
| ▸ | DRD2 | P14416 | 5/20 | 0.37 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.37 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.37 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.37 |
| ▸ | PANK3 | Q9H999 | 1/20 | 0.37 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4722765 | 0.86 | GPR119 (0.46) | ACHEPCSK9DRD2UTS2RMAPT | |
| SCHEMBL4765791 | 0.82 | UTS2R (0.41) | OGAPCSK9DRD2UTS2R | |
| SCHEMBL4505689 | 0.80 | ACHE (0.43) | ACHECHRNA7 | |
| SCHEMBL23593462 | 0.77 | ACHE (0.40) | ACHEPTPN11DRD2DDB1CRBN | |
| SCHEMBL23578977 | 0.76 | ALOX5AP (0.40) | ACHEDDB1CRBN | |
| SCHEMBL4766157 | 0.76 | HRH3 (0.45) | OGAPCSK9DRD2UTS2R | |
| SCHEMBL19015403 | 0.76 | ACHE (0.61) | ACHEPTPN11DDB1CRBNCHRNA7 | |
| SCHEMBL25063568 | 0.75 | DRD2 (0.40) | ACHEDRD2DDB1CRBN | |
| SCHEMBL22455152 | 0.75 | NCF1 (0.51) | DRD2UTS2RMAPT | |
| SCHEMBL29357542 | 0.75 | NCF1 (0.51) | DRD2UTS2RMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1917262-A1 | PIPERIDINE AND PIPERAZINE DERIVATIVES AS P2X3 ANTAGONISTS | F.HOFFMANN-LA ROCHE AG (CH) | 2008-05-07 | — | — | EP | disclosed |
| WO-2007020194-A1 | PIPERIDINE AND PIPERAZINE DERIVATIVES AS P2X3 ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2007-02-22 | — | — | WO | disclosed |