Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 2/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | MOGAT2 | Q3SYC2 | 3/20 | 0.38 |
| ▸ | MGAT2 | Q10469 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 3/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4728980 | 0.91 | DRD3 (0.42) | DRD3DRD2KCNH2CNR2ALDH1A1 | |
| SCHEMBL4725768 | 0.88 | MAPT (0.51) | DRD3CNR2ALDH1A1MAPTUSP2 | |
| SCHEMBL4727610 | 0.87 | UCHL1 (0.51) | DRD3DRD2KCNH2CNR2ALDH1A1 | |
| SCHEMBL4728012 | 0.87 | CES1 (0.48) | DRD3DRD2KCNH2CNR2ALDH1A1 | |
| SCHEMBL4729811 | 0.87 | ALDH1A1 (0.50) | DRD3CNR2ALDH1A1MAPTMOGAT2 | |
| SCHEMBL4726510 | 0.87 | CNR2 (0.49) | DRD3DRD2KCNH2CNR2ALDH1A1 | |
| SCHEMBL4726548 | 0.85 | CRHBP (0.48) | DRD3DRD2KCNH2ALDH1A1MAPT | |
| SCHEMBL4730511 | 0.85 | FFAR1 (0.44) | DRD3DRD2KCNH2CNR2ALDH1A1 | |
| SCHEMBL4725454 | 0.85 | DRD3 (0.57) | DRD3DRD2KCNH2ALDH1A1MAPT | |
| SCHEMBL4725306 | 0.84 | POLB (0.54) | DRD3ALDH1A1MAPTKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008026046-A1 | MORPHOLINE D3 DOPAMINE ANTAGONISTS | PFIZER PRODUCTS INC. (US) | 2008-03-06 | — | — | WO | claimed |
| WO-2008026046-A1 | MORPHOLINE D3 DOPAMINE ANTAGONISTS | PFIZER PRODUCTS INC. (US) | 2008-03-06 | — | — | WO | disclosed |