Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 1/20 | 0.45 |
| ▸ | CNR2 | P34972 | 4/20 | 0.41 |
| ▸ | EDNRB | P24530 | 2/20 | 0.40 |
| ▸ | EDNRA | P25101 | 2/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 4/20 | 0.40 |
| ▸ | GSPT1 | P15170 | 1/20 | 0.40 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.40 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.40 |
| ▸ | MOGAT2 | Q3SYC2 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | MGAT2 | Q10469 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | SGK1 | O00141 | 1/20 | 0.38 |
| ▸ | CCR2 | P41597 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4727604 | 0.86 | MEN1 (0.47) | DRD3CNR2MOGAT2MAPTMGAT2 | |
| SCHEMBL4729815 | 0.83 | ALDH1A1 (0.47) | DRD3CNR2MOGAT2MAPTMGAT2 | |
| SCHEMBL4727167 | 0.83 | DRD3 (0.45) | DRD3CNR2MOGAT2MAPTMGAT2 | |
| SCHEMBL4729847 | 0.82 | MOGAT2 (0.46) | DRD3CNR2MOGAT2MGAT2SGK1 | |
| SCHEMBL4778150 | 0.81 | PGR (0.50) | DRD3CNR2MAPTTP53 | |
| SCHEMBL4726498 | 0.81 | ALDH1A1 (0.44) | DRD3DDB1CRBNMAPTTP53 | |
| SCHEMBL4728012 | 0.81 | CES1 (0.48) | DRD3CNR2MOGAT2MAPTMGAT2 | |
| SCHEMBL4726510 | 0.80 | CNR2 (0.49) | DRD3CNR2MOGAT2MAPTKCNH2 | |
| SCHEMBL4725656 | 0.80 | KMT2A (0.45) | DRD3CNR2MAPT | |
| SCHEMBL4729823 | 0.80 | DRD3 (0.49) | DRD3CNR2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008026046-A1 | MORPHOLINE D3 DOPAMINE ANTAGONISTS | PFIZER PRODUCTS INC. (US) | 2008-03-06 | — | — | WO | claimed |
| WO-2008026046-A1 | MORPHOLINE D3 DOPAMINE ANTAGONISTS | PFIZER PRODUCTS INC. (US) | 2008-03-06 | — | — | WO | disclosed |