Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NISCH | Q9Y2I1 | 5/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | RECQL | P46063 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.53 |
| ▸ | PDCD1LG2 | Q9BQ51 | 1/20 | 0.52 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.52 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.50 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.50 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL545936 | 0.75 | NISCH (0.56) | NISCHLMNARECQLCYP1A2KDM4E | |
| SCHEMBL30373695 | 0.75 | NISCH (0.56) | NISCHLMNARECQLCYP1A2KDM4E | |
| SCHEMBL5879623 | 0.75 | NISCH (0.51) | NISCHLMNACYP1A2KDM4EPDCD1LG2 | |
| SCHEMBL7279147 | 0.73 | P4HA1 (0.58) | NISCHLMNACYP1A2KDM4EPDCD1LG2 | |
| SCHEMBL523059 | 0.73 | LMNA (0.96) | NISCHLMNARECQL | |
| SCHEMBL30373758 | 0.72 | NISCH (1.00) | NISCHLMNACYP1A2KDM4EALDH1A1 | |
| SCHEMBL8188355 | 0.72 | LMNA (0.92) | NISCHLMNARECQL | |
| SCHEMBL1345182 | 0.72 | NISCH (1.00) | NISCHLMNACYP1A2KDM4EALDH1A1 | |
| SCHEMBL197456 | 0.71 | CCR1 (0.46) | LMNAADRA2AADRA2BADRA2C | |
| SCHEMBL31504098 | 0.71 | CCR1 (0.46) | LMNAADRA2AADRA2BADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008010796-A1 | PROCESS FOR PREPARING PYRIDINE-2-CARBOXAMIDES AND INTERMEDIATES THEREFOR | RENAISSANCE MEDICINE, LLC (US) | 2008-01-24 | — | — | WO | claimed |
| WO-2008010794-A1 | PHARMACEUTICAL PREPARATIONS OF CRYSTALLINE LAZABEMIDE | RENAISSANCE MEDICINE, LLC (US) | 2008-01-24 | — | — | WO | disclosed |
| WO-2008010796-A1 | PROCESS FOR PREPARING PYRIDINE-2-CARBOXAMIDES AND INTERMEDIATES THEREFOR | RENAISSANCE MEDICINE, LLC (US) | 2008-01-24 | — | — | WO | disclosed |
| WO-2008010796-A1 | PROCESS FOR PREPARING PYRIDINE-2-CARBOXAMIDES AND INTERMEDIATES THEREFOR | RENAISSANCE MEDICINE, LLC (US) | 2008-01-24 | — | — | WO | disclosed |