Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 8/20 | 0.44 |
| ▸ | CCR1 | P32246 | 1/20 | 0.40 |
| ▸ | GRM5 | P41594 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | DRD4 | P21917 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | APP | P05067 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.38 |
| ▸ | S1PR2 | O95136 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12469550 | 0.86 | HSD11B1 (0.46) | HSD11B1GRM5OPRM1 | |
| SCHEMBL18711298 | 0.85 | RORC (0.44) | HSD11B1CYP2C19HTT | |
| SCHEMBL4725181 | 0.83 | OPRM1 (0.55) | CCR1DRD2DRD4DRD3CYP3A4 | |
| SCHEMBL3790649 | 0.81 | KMT2A (0.51) | HSD11B1CYP2C19APPCYP3A4CYP2C9 | |
| SCHEMBL5807539 | 0.81 | FASN (0.47) | — | |
| SCHEMBL18701924 | 0.81 | DRD2 (0.41) | HSD11B1DRD2DRD4DRD3CYP2C19 | |
| Hydrochloric Acid SCHEMBL3428799 | 0.80 | OPRM1 (0.52) | CCR1DRD2DRD4DRD3CYP3A4 | |
| Hydrochloric Acid SCHEMBL3428801 | 0.80 | OPRM1 (0.52) | CCR1DRD2DRD4DRD3CYP3A4 | |
| SCHEMBL2425390 | 0.79 | HSD11B1 (0.49) | HSD11B1DRD2DRD4DRD3OPRM1 | |
| SCHEMBL1581427 | 0.79 | OPRM1 (0.51) | CCR1DRD2DRD4DRD3CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008012623-A1 | BENZIMIDAZOLYL COMPOUNDS AS POTENTIATORS OF MGLUR2 SUBTYPE OF GLUTAMATE RECEPTOR | PFIZER PRODUCTS INC. (US) | 2008-01-31 | — | — | WO | disclosed |