Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 5/20 | 0.51 |
| ▸ | NPC1 | O15118 | 4/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.42 |
| ▸ | RAF1 | P04049 | 1/20 | 0.42 |
| ▸ | BRAF | P15056 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | CASP3 | P42574 | 1/20 | 0.42 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4415213 | 0.90 | RAF1 (0.45) | RAB9ANPC1KMT2ARAF1BRAF | |
| SCHEMBL5604188 | 0.89 | RAB9A (0.52) | RAB9ANPC1KDM4EHPGDKMT2A | |
| SCHEMBL14473330 | 0.87 | KDM4E (0.47) | RAB9ANPC1KDM4EHPGDKMT2A | |
| SCHEMBL4420133 | 0.86 | RAB9A (0.48) | RAB9ANPC1KDM4EHPGDKMT2A | |
| SCHEMBL4411700 | 0.86 | MEN1 (0.43) | KDM4EKMT2ATSHRALDH1A1CYP1A2 | |
| SCHEMBL4413480 | 0.84 | RAF1 (0.45) | NPC1KMT2ASMN1; SMN2RAF1BRAF | |
| SCHEMBL4551944 | 0.83 | NR1H4 (0.46) | KMT2ATSHRRAF1BRAFMEN1 | |
| SCHEMBL4420074 | 0.82 | RAF1 (0.49) | RAB9ANPC1KDM4ELMNARAF1 | |
| SCHEMBL14473326 | 0.82 | RAB9A (0.51) | RAB9ANPC1HPGDKMT2ATSHR | |
| SCHEMBL4412543 | 0.82 | ALDH1A1 (0.42) | RAB9ANPC1KDM4EKMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035005-A2 | THERAPY USING CYTOKINE INHIBITORS | Kemia, INC. (US) | 2009-03-18 | — | — | EP | disclosed |
| WO-2007146712-A2 | THERAPY USING CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-12-21 | — | — | WO | disclosed |
| WO-2007075896-A2 | HETEROCYCLIC CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-07-05 | — | — | WO | disclosed |
| WO-2007075896-A2 | HETEROCYCLIC CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-07-05 | — | — | WO | disclosed |