SCHEMBL472951

SCHEMBL472951

C#CCOC(=O)C1C(C=O)C1(C)C

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 3/20 0.49
POLB P06746 1/20 0.36
TDP1 Q9NUW8 3/20 0.35
TSHR P16473 2/20 0.35
MEN1 O00255 1/20 0.35
KMT2A Q03164 1/20 0.35
ZDHHC20 Q5W0Z9 1/20 0.33
NPC1 O15118 1/20 0.32
L3MBTL1 Q9Y468 2/20 0.32
CYP1A2 P05177 1/20 0.32
CYP3A4 P08684 1/20 0.32
CYP2D6 P10635 1/20 0.32
CYP2C9 P11712 1/20 0.32
CYP2C19 P33261 1/20 0.32
ADRA2A P08913 1/20 0.32
CNR1 P21554 1/20 0.32
ATM Q13315 1/20 0.32
SLC1A3 P43003 1/20 0.31
SLC1A2 P43004 1/20 0.31
SLC1A1 P43005 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3682642 0.85 LMNA (0.47) LMNAPOLBTDP1TSHRMEN1
SCHEMBL3682641 0.85 LMNA (0.47) LMNAPOLBTDP1TSHRMEN1
SCHEMBL3678630 0.83 LMNA (0.54) LMNAPOLBTDP1TSHRMEN1
SCHEMBL3678627 0.83 LMNA (0.54) LMNAPOLBTDP1TSHRMEN1
SCHEMBL1150268 0.82 LMNA (0.69) LMNATDP1TSHRMEN1KMT2A
SCHEMBL11291535 0.82 LMNA (0.69) LMNATDP1TSHRMEN1KMT2A
SCHEMBL10952942 0.82 LMNA (0.69) LMNATDP1TSHRMEN1KMT2A
SCHEMBL358792 0.82 LMNA (0.69) LMNATDP1TSHRMEN1KMT2A
SCHEMBL1150270 0.82 LMNA (0.69) LMNATDP1TSHRMEN1KMT2A
SCHEMBL359355 0.79 LMNA (0.51) LMNATDP1TSHRMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2412702-B1 METHOD FOR PRODUCING CYCLOPROPANECARBOXYLIC ACID ESTER SUMITOMO CHEMICAL CO (JP) 2014-12-03 EP disclosed
US-20120029227-A1 METHOD FOR PRODUCING CYCLOPROPANECARBOXYLIC ACID ESTER SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2012-02-02 US disclosed
EP-2412702-A1 METHOD FOR PRODUCING CYCLOPROPANECARBOXYLIC ACID ESTER Sumitomo Chemical Company, Limited (JP) 2012-02-01 EP disclosed
US-7700799-B2 Method for producing (2-formyl-1-alkenyl) cyclopropane compound SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2010-04-20 US disclosed
EP-1731564-B1 Water tree retarding composition BOREALIS TECH OY (FI) 2010-03-10 EP disclosed
US-20090137839-A1 METHOD FOR PRODUCING (2-FORMYL-1-ALKENYL) CYCLOPROPANE COMPOUND SUMITOMO CHEMICAL COMPANY, LTD. (JP) 2009-05-28 US disclosed
US-7498459-B2 Method for producing (1-alkenyl)cyclopropane compound SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2009-03-03 US disclosed
US-20070197818-A1 Method for producing (1-alkenyl) cyclopropane compound SUMITOMO CHEMICAL COMPANY, LIMITED 2007-08-23 US disclosed
WO-2006131266-A1 WATER TREE RETARDING COMPOSITION BOREALIS TECHNOLOGY OY (FI) 2006-12-14 WO disclosed
EP-1731564-A1 Water tree retarding composition Borealis Technology Oy (FI) 2006-12-13 EP disclosed
EP-1728781-A1 PROCESS FOR PRODUCTION OF (1-ALKENYL)CYCLOPROPANES Sumitomo Chemical Company, Limited (JP) 2006-12-06 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120029227-A1 METHOD FOR PRODUCING CYCLOPROPANECARBOXYLIC ACID ESTER PCCA, COASY, GRHPR LMNA 1488/4885POLB 2404/4885TDP1 4158/4885
US-20090137839-A1 METHOD FOR PRODUCING (2-FORMYL-1-ALKENYL) CYCLOPROPANE COMPOUND ACSL3, ACSL1, ARL1 LMNA 2696/4885POLB 2007/4885TDP1 4458/4885
US-20070197818-A1 Method for producing (1-alkenyl) cyclopropane compound ACSL3, ARL1, ACSL1 LMNA 3763/4885POLB 2766/4885TDP1 4490/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.